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UnknownA Highly Selective and Sensitive Turn-On Fluorescent Chemosensor Based on Rhodamine 6G for Iron(III).
Recently, more and more rhodamine derivatives have been used as fluorophores to construct sensors due to their excellent spectroscopic properties. A rhodamine-based fluorescent and colorimetric Fe(3+) chemosensor 3',6'-bis(ethylamino)-2-acetoxyl-2',7'-dimethyl-spiro[1H-isoindole-1,9'-[9H]xanthen]-3(...
S-EPMC4280826 | biostudies-literature
UnknownTargeting miR-23a in CD8+ cytotoxic T lymphocytes prevents tumor-dependent immunosuppression.
CD8(+) cytotoxic T lymphocytes (CTLs) have potent antitumor activity and therefore are leading candidates for use in tumor immunotherapy. The application of CTLs for clinical use has been limited by the susceptibility of ex vivo-expanded CTLs to become dysfunctional in response to immunosuppressive ...
S-EPMC4348954 | biostudies-literature
UnknownNomogram to predict 3-month unfavorable outcome after thrombectomy for stroke.

Background

Mechanical thrombectomy (MT) is an effective treatment for large-vessel occlusion in acute ischemic stroke, however, only some revascularized patients have a good prognosis. For stroke patients undergoing MT, predicting the risk of unfavorable outcomes and adjusting the treatment ...
S-EPMC8941794 | biostudies-literature
UnknownDiagnostic value of pleural fluid neuron-specific enolase for malignant pleural effusion.

Background

Neuron-specific enolase (NSE) in pleural fluid has been proposed as a promising diagnostic biomarker. However, existing studies on the diagnostic accuracy of NSE have reported inconsistent results. This study aimed to assess the accuracy of NSE in differentiating malignant pleural...
S-EPMC12780435 | biostudies-literature
UnknownCepharanthine Prevents Estrogen Deficiency-Induced Bone Loss by Inhibiting Bone Resorption.
Osteoporosis is a common health problem worldwide caused by an imbalance of bone formation vs. bone resorption. However, current therapeutic approaches aimed at enhancing bone formation or suppressing bone resorption still have some limitations. In this study, we demonstrated for the first time that...
S-EPMC5880888 | biostudies-literature
UnknownEffect of ATorvastatin On Chronic subdural Hematoma (ATOCH): a study protocol for a randomized controlled trial.

Background

Chronic subdural hematoma (CSDH) is a common disease that is more prevalent in older people. Surgical intervention is a safe treatment of choice. However, the recurrence rate is relatively high and the outcome is not always satisfactory among surgically treated patients. It is bel...
S-EPMC4652431 | biostudies-literature
ProteomicsA CLIC1 network coordinates matrix stiffness and the Warburg effect to promote tumor growth in pancreatic cancer
The proteomics cohort with PET-CT information (n = 8) were divided into two groups according to the SUV-max, and gene expression in these two groups of PDAC tissues was screened for glucose metabolism-correlated DEGs
ORGANISM(S): Homo Sapiens 
PXD053962 |
UnknownEarly Death and Survival of Patients With Acute Promyelocytic Leukemia in ATRA Plus Arsenic Era: A Population-Based Study.
Most randomized trials for acute promyelocytic leukemia (APL) have investigated highly selected patients under idealized conditions, and the findings need to be validated in the real world. We conducted a population-based study of all APL patients in Zhejiang Province, China, with a total population...
S-EPMC8637823 | biostudies-literature
UnknownPAM-flexible adenine base editing rescues hearing loss in a humanized MPZL2 mouse model harboring an East Asian founder mutation.
Hearing loss is one of the most prevalent sensory disorders, but no commercial biological treatments are currently available. Here, we identify an East Asia-specific founder mutation, the homozygous c.220 C > T mutation in MPZL2, that contributes to a significant proportion of hereditary deafness ca...
S-EPMC12325647 | biostudies-literature
UnknownImmune checkpoint inhibitors and anti-vascular endothelial growth factor antibody/tyrosine kinase inhibitors with or without transarterial chemoembolization as first-line treatment for advanced hepatocellular carcinoma (CHANCE2201): a target trial emulation study.

Background

The role of transarterial chemoembolization (TACE) in the treatment of advanced hepatocellular carcinoma (HCC) is unconfirmed. This study aimed to assess the efficacy and safety of immune checkpoint inhibitors (ICIs) plus anti-vascular endothelial growth factor (anti-VEGF) antibod...
S-EPMC11090892 | biostudies-literature
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