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TranscriptomicsCritical role for the DNA receptor AIM2 in stem-cell proliferation and cancer
Colorectal cancer is a leading cause of cancer-related deaths. Mutations in the innate immune receptor AIM2 are frequently identified in patients with colorectal cancer, but how AIM2 modulates colonic tumorigenesis is unknown. Here, we found that Aim2-deficient mice were hypersusceptible to colonic ...
ORGANISM(S): Mus musculus 
2015-07-15 | E-GEOD-69436 | biostudies-arrayexpress
ProteomicsIdentification of p72-interacting proteins in porcine alveolar macrophages
To explore the potential mechanisms regulating p72 stability, we performed co-immunoprecipitation using an anti-p72 antibody in ASFV-infected PAMs, followed by mass spectrometry analysis to identify host factors interacting with p72.
ORGANISM(S): Sus Scrofa Domesticus 
2026-01-18 | PXD073232 |
TranscriptomicsMulti-organ mapping of cancer risk
Cancers are distributed unevenly across the body; but the importance of cell intrinsic factors such as stem cell function in determining organ cancer risk is unknown. Therefore, we used cre-recombination of conditional lineage tracing, oncogene and tumour suppressor alleles to define populations of...
ORGANISM(S): Mus musculus 
2016-07-01 | E-GEOD-78076 | biostudies-arrayexpress
TranscriptomicsCancers originate preferentially in adult tissue stem cells
Stem cells have long been regarded as a potential origin of cancer. But cancers could also arise from mutated, differentiated cells that reacquire stem cell properties. Here, in mice harboring conditional oncogenic and lineage tracing alleles, we show that cancers develop from Prom1+ (CD133) cells...
ORGANISM(S): Mus musculus 
2013-09-01 | E-GEOD-40634 | biostudies-arrayexpress
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