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TranscriptomicsMidgut transcriptome response to a Cry toxin in the diamondback moth, Plutella xylostella (Lepidoptera: Plutellidae)
We investigate the functional complexity of the Plutella xylostella transcriptome in defending against a Bt toxin using Illumina sequencing technology. Over 2,900 differentially expressed unigenes were obtained in resistant P. xylostella comparison to their susceptible counterpart. All the P. xylost...
ORGANISM(S): Plutella xylostella 
2014-05-01 | E-GEOD-46399 | biostudies-arrayexpress
UnknownMK-8353: Discovery of an Orally Bioavailable Dual Mechanism ERK Inhibitor for Oncology.
Not available
S-EPMC6047169 | biostudies-literature
MetabolomicsAbsolute quantification of serum cytokines and metabolome reveals the glycylproline regulating antibody-fading in convalescent COVID-19 patients

The COVID-19 pandemic has incurred tremendous costs worldwide and is still threatening public health in the 'new normal'. The association between neutralizing antibody levels and metabolic alterations in convalescent patients with COVID-19 is still poorly understood. In the present work, we condu...

2024-08-26 | MTBLS3305 | MetaboLights
UnknownDiscovery of MK-7145, an Oral Small Molecule ROMK Inhibitor for the Treatment of Hypertension and Heart Failure.
Not available
S-EPMC4948008 | biostudies-literature
GenomicsINSPIRE - Investigator-initiated Phase 2 Study of Pembrolizumab Immunological Response in Metastatic Solid Tumors
Whole exome and RNA sequencing source data for: Clouthier, D.L., Lien, S.C., Yang, S.Y.C. et al. An interim report on the investigator-initiated phase 2 study of pembrolizumab immunological response evaluation (INSPIRE). j. immunotherapy cancer 7, 72 (2019). https://doi.org/10.1186/s40425-019-0541-...
EGAS00001003280 | EGA
UnknownIncreasing Vitamin K2 Synthesis in Bacillus subtilis by Controlling the Expression of MenD and Stabilizing MenA.
Not available
S-EPMC11487629 | biostudies-literature
MetabolomicsComputational mass spectrometry accelerates C=C position-resolved untargeted lipidomics using oxygen attachment dissociation
Mass spectrometry-based untargeted lipidomics has revealed the lipidome atlas of living organisms at the molecular species level. Despite the double bond (C=C) position being a crucial factor for enzyme preference, cellular membrane milieu, and biological activity, the C=C defined structures have no...
2022-11-09 | MTBLS5861 | MetaboLights
ProteomicsHexameric VCP/p97 reprograms transcription by organizing enhancers with the ASPSCR1-TFE3 fusion oncoprotein
Aberrant transcription in alveolar soft part sarcoma (ASPS) is orchestrated by the fusion oncoprotein, ASPSCR1-TFE3, resulting from a gene fusion created by a t(X;17) chromosomal translocation. Proteomic analysis of co-immunoprecipitated ASPSCR1-TFE3 complexes revealed strong enrichment of VCP/p97, ...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2023-11-23 | PXD022515 | Pride
Asps Ip-ms Tmt 
MetabolomicsExploring the effect of estrogen on Candida albicans hyphal cell wall glycans and ergosterol synthesis
Increased levels of 17-β estradiol (E2) due to pregnancy in young women or to hormonal replacement therapy in postmenopausal women have long been associated with an increased risk of yeast infections. Nevertheless, the effect underlying the role of E2 in Candida albicans infections is not wel...
2025-09-11 | MTBLS5821 | MetaboLights
UnknownAssociations between diffusion kurtosis imaging metrics and neurodevelopmental outcomes in neonates with low-grade germinal matrix and intraventricular hemorrhage.
Not available
S-EPMC11252380 | biostudies-literature
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