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ProteomicsDMLL alleviates ulcerative colitis in mice
The natural compound DMLL alleviates DSS-induced experimental colitis through modulating gut microbiota and metabolic dysbiosis. The phylum of Bacteroidota and genera of norank_f_Muribaculaceae and Ruminococcus with beneficial potential for UC were the major gut flora regulated by DMLL. In terms of ...
ORGANISM(S): Mus Musculus 
2025-01-13 | PXD059704 |
ProteomicsTargeted protein degradation reveals Pol II heterogeneity and functional diversity
RNA polymerase II (Pol II) subunits are thought to be involved in various transcription-associated processes, but it is unclear whether they play different regulatory roles in modulating gene expression. Here, we performed nascent and mature transcript sequencing after the acute degradation of 12 ma...
ORGANISM(S): Mus <genus> 
2022-08-09 | PXD035866 |
ProteomicsDDX1 Methylation Mediated MATR3 Splicing Regulates Intervertebral Disc Degeneration by Initiating Chromatin Reprogramming
Low back pain (LBP), often caused by intervertebral disc degeneration (IVDD), poses a major challenge in aging populations. DDX1, an RNA-binding protein, plays key roles in RNA metabolism but its function in IVDD remains unclear. We identify DDX1 as a non-histone substrate of lysine methyltransferas...
ORGANISM(S): Homo Sapiens 
PXD064432 |
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