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TranscriptomicsTranscription profiling of mouse muscle mutant to reveals skeletal muscle growth and fiber composition in mice are regulated through the transcription factors STAT5a/b
In skeletal muscle, STAT5a/b transcription factors are critical for normal postnatal growth, whole-animal glucose homeostasis, and local IGF-1 production. These observations have led us to hypothesize that STAT5a/b are critical for maintenance of normal muscle mass and function. To investigate thi...
ORGANISM(S): Mus musculus 
2009-09-05 | E-GEOD-14710 | biostudies-arrayexpress
TranscriptomicsThe transcription factors STAT5a/b negatively regulate cell proliferation through the activation of cdkn2b and cdkn1a expression
Although the cytokine-inducible transcription factors STAT5a/b promote proliferation of a wide range of cell types, there are cell- and context specific cases in which loss of STAT5a/b results in enhanced cell proliferation. Here we report that loss of STAT5a/b from mouse embryonic fibroblasts (MEFs...
ORGANISM(S): Mus musculus 
2010-11-15 | E-GEOD-21861 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse wild type and Stat5a or 5b knock-out blood cells treated with GM-CSF to induce granulopoiesis
GM-CSF controls the development of granulocytes but little is known about the contribution of the downstream mediating transcription factor STAT5A/B. To elucidate this pathway, we generated mice lacking the Stat5a and 5b genes in blood cells. Peripheral neutrophils were decreased and administratio...
ORGANISM(S): Mus musculus 
2009-10-10 | E-GEOD-14672 | biostudies-arrayexpress
TranscriptomicsLoss of Olfactomedin 4 Leads to Neoplastic Progression in the Prostate
Purpose: To explore the mechanisms underlying increased tumorigenesis of Olfm4-deficient murine prostate. Experiment design: Comparison of gene expression between Olfm4-knockout and wild-type mice at 3 months of age in the prostate tissue. Experimental procedures: Total RNA was purified from whole p...
ORGANISM(S): Mus musculus 
2016-07-06 | E-GEOD-39989 | biostudies-arrayexpress
TranscriptomicsGenome-wide analyses reveal the extent of opportunistic STAT5 binding that does not yield transcriptional activation of neighboring genes
Stat5+/- mice were bred into the C57BL/6 background. Stat5+/- mice were intercrossed and mouse embryonic fibroblasts (MEFs) were isolated from 12.5-13.5-day WT or Stat5-/- fetuses. The retroviral-expression vector carrying a wild-type Stat5A gene based on an MSCV-IRES-GFP backbone (gift from Richard...
ORGANISM(S): Mus musculus 
2012-03-14 | E-GEOD-33688 | biostudies-arrayexpress
ProteomicsQ-TOF/MS detected results of the Lysostaphin and recombinant Lysostaphin-ELP(V)90
This study engineered a recombinant lysostaphin (Lst) variant, Lst-ELP(V)₉₀, as a therapeutic candidate for prosthetic explant biofilm infections caused by methicillin-resistant Staphylococcus aureus (MRSA). Compared with the wild-type (WT) lysostaphin, the recombinant construct exhibited markedly i...
ORGANISM(S): Escherichia coli 
2026-08-13 | PXD080789 | Pride
Lysostaphin Elp Mrsa Q/tof/ms Biofilm 
ProteomicsTRIM28 is an E3 ligase of IRP2 suppressing ischemia/reperfusion-induced myocardial ferroptosis
Myocardial ischemia/reperfusion (I/R) injury is a common and severe clinical complication in patients with ischemic heart disease (IHD) after reperfusion therapy. Effective therapeutic strategies for myocardial I/R injury remain limited. Ferroptosis is a form of regulated cell death characterized by...
ORGANISM(S): Rattus Norvegicus 
2025-12-28 | PXD072478 |
ProteomicsLow-dose metformin targets the lysosome-AMPK pathway through PEN2
Metformin is the most prescribed anti-diabetic medicine, and has also been shown to have other various benefits, such as anti-aging and anti-cancer effects. For clinical doses of metformin, it is known that AMPK plays a major role; however, the direct molecular target of metformin remains unclear. H...
ORGANISM(S): Homo Sapiens Mus Musculus 
2021-12-01 | PXD030090 |
ProteomicsSerum proteomics of individuals with MASLD under resistance starch intervention
Searching for baseline proteins that contribute to the individual response to RS intervention
ORGANISM(S): Homo Sapiens 
2025-09-24 | PXD068798 |
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