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MetabolomicsThe killing mechanism of teixobactin against methicillin-resistant Staphylococcus aureus (MRSA): An untargeted metabolomics study

The discovery of antibiotics has led to the effective treatment of bacterial infections that were otherwise fatal and has had a transformative effect on modern medicine. Teixobactin is an unusual depsipeptide natural product that was recently discovered from a previously unculturable soil bacteri...

2020-04-30 | MTBLS1569 | MetaboLights
MetabolomicsDeciphering the Anti-Biofilm Mechanism of Anthraquinone-2-Carboxylic Acid Against MRSA by Comprehensive Multi-Omics Analysis

Background: Methicillin-resistant Staphylococcus aureus (MRSA) biofilms exhibit high levels of drug resistance and cause nosocomial infections in humans, thus posing a sustainable global health threat. This underscores the critical need to develop novel antibiofilm therapeutics with high efficacy...

2025-09-18 | MTBLS13012 | MetaboLights
ProteomicsMRSA and MSSA
A strategy for the high-throughput screening of a peptide nucleic acid (PNA) encoded peptide library to allow the identification of MRSA and MSSA selective peptides including AMPs. This novel screening approach allows simultaneous screening of cell selective peptides with different uptake mechanisms...
ORGANISM(S): Staphylococcus aureus 
2012-12-01 | E-MEXP-3327 | biostudies-arrayexpress
TranscriptomicsRole of the accessory gene regulator agr in community-associated MRSA pathogenesis
The success of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) as pathogens is due to a combination of antibiotic resistance with high virulence. However, evolution of the exceptional virulence potential of CA-MRSA is not understood. Our previous study indicated that diffe...
ORGANISM(S): Staphylococcus aureus 
2011-03-29 | E-GEOD-18793 | biostudies-arrayexpress
TranscriptomicsGenetic Variation in Spatio-Temporal Confined USA300 Community-Associated MRSA Isolates: A Shift from Clonal Dispersion to Genetic Evolution?
Introduction Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) are increasingly isolated, with USA300-0114 being the predominant clone in the USA. Comparative whole genome sequencing of USA300 isolates collected in 2002, 2003 and 2005 showed a limited number of single nucleo...
ORGANISM(S): Staphylococcus aureus 
2011-04-15 | E-BUGS-108 | biostudies-arrayexpress
TranscriptomicsTranscriptional events during lung recovery from MRSA infection: a mouse pneumonia model
Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) is an emerging threat to human health throughout the world. Rodent MRSA pneumonia models mainly focus on the early innate immune responses to MRSA infection. However, the molecular pattern and mechanisms of recovery from MRSA...
ORGANISM(S): Mus musculus 
2013-11-12 | E-GEOD-36587 | biostudies-arrayexpress
TranscriptomicsPanton-Valentine Leukocidin Does Not Impact Virulence of Community-associated MRSA
Panton-valentine leukocidin (PVL) has been linked to worldwide emergence of community-associated methicillin resistant Staphylococcus aureus (CA-MRSA) -- its role in virulence in unclear. Here we show that PVL had no effect on global gene expression of prominent CA-MRSA strains nor did it affect ba...
ORGANISM(S): Staphylococcus aureus 
2010-06-19 | E-GEOD-8677 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of S. aureus to investigate an outbreak of severe infections with community-acquired methicillin-resistant Staphylococcus aureus carrying the Panton-Valentine leukocidin following immunization - duplicate of E-BUGS-45
BACKGROUND: Infections with community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) are emerging worldwide. We investigated an outbreak of severe CA-MRSA infections in children following out-patient vaccination. METHODS AND FINDINGS: We carried out a field investigation after adve...
ORGANISM(S): Staphylococcus aureus 
2009-01-16 | E-BUGS-45 | biostudies-arrayexpress
TranscriptomicsExpression data from Staphylococcus aureus ATCC 25923 (antibiotic sensitive) and ATCC 33591 (MRSA)
S. aureus ATCC 25923 is performance standard for antimicrobial susceptibility testing. S. aureus ATCC 33591 showed resistance against erytrhromycin, penicillin, and streptomycin. We used microarray to compare RNA expression between sensitive and resistant strain of S. aureus as a preliminary researc...
ORGANISM(S): Staphylococcus aureus 
2010-09-15 | E-GEOD-18289 | biostudies-arrayexpress
ProteomicsProteome Differences between Daptomycin-Resistant and WT MRSA Biofilms after Elasnin Treatment
A recent study reported that daptomycin-resistant MRSA (DAPR) strain biofilm is more resistant to daptomycin and vancomycin, as compared to the WT strain biofilm. This pose a great danger since DAPR MRSA is prevalent in clinics and they often form biofilms in medical devices. In this study, we inves...
ORGANISM(S): Staphylococcus aureus 
2021-11-11 | PXD024005 | Pride
Daptomycin-resistant Mrsa Elasnin Biofilms 
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