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ProteomicsProteomic Investigation of Multiple Methicillin-Resistant Staphylococcus aureus strains with distinct Daptomycin Tolerance and Resistance Phenotypes
Several groups have shown that through evolution experiments, tolerance and resistance evolved rapidly under cyclic antibiotic treatment. In other words, intermittent antibiotic exposure performed in a typical adaptive laboratory evolution (ALE) experiments will “train” the bacteria to become tolera...
ORGANISM(S): Staphylococcus aureus 
2022-07-14 | PXD026741 | Pride
Proteomics Daptomycin Methicillin-resistant staphylococcus aureus Adaptive laboratory evolution Tolerance 
ProteomicsProteome Differences between Daptomycin-Resistant and WT MRSA Biofilms after Elasnin Treatment
A recent study reported that daptomycin-resistant MRSA (DAPR) strain biofilm is more resistant to daptomycin and vancomycin, as compared to the WT strain biofilm. This pose a great danger since DAPR MRSA is prevalent in clinics and they often form biofilms in medical devices. In this study, we inves...
ORGANISM(S): Staphylococcus aureus 
2021-11-11 | PXD024005 | Pride
Daptomycin-resistant Mrsa Elasnin Biofilms 
TranscriptomicsIn vitro transcriptomic comparison of daptomycin-resistant Staphylococcus aureus
Mutants from SG511 and NCTC8325 (wild type isolates) resistant to daptomycin were obtained following serial passage experiments in vitro. Transcriptomic experiments showed alteration in the expression of genes involved in various pathways including general metabolism, cell wall regulon and lipid met...
ORGANISM(S): Staphylococcus aureus subsp. aureus NCTC 8325 
2015-11-01 | E-GEOD-50842 | biostudies-arrayexpress
ProteomicsProteomic Investigation of Evolved Daptomycin-Tolerant MRSA due to Mutation in YycH
Several groups have shown that through evolution experiments, tolerance and resistance evolved rapidly under cyclic antibiotic treatment. In other words, intermittent antibiotic exposure performed in a typical adaptive laboratory evolution (ALE) experiments will “train” the bacteria to become tolera...
ORGANISM(S): Staphylococcus aureus 
2022-07-16 | PXD031078 | Pride
Proteomics Daptomycin Methicillin-resistant s. aureus Adaptive laboratory evolution Tolerance Yych 
GenomicsIn vitro transcriptomic comparison of daptomycin-resistant Staphylococcus aureus
In vitro transcriptomic comparison of daptomycin-resistant Staphylococcus aureus
PRJNA219158 | ENA
TranscriptomicsDaptomycin stimulon in Bacillus subtilis W168
Abstract of associated manuscript: Daptomycin is the first of a new class of cyclic lipopeptide antibiotics used against multidrug-resistant Gram-positive pathogens. The proposed mechanism of action involves disruption of the functional integrity of the bacterial membrane in a Ca2+-dependent manner....
ORGANISM(S): Bacillus subtilis 
2008-12-10 | E-GEOD-13900 | biostudies-arrayexpress
GenomicsGenomic and Long-Term Transcriptomic Imprints Related to the Daptomycin Mechanism of Action Occurring in Daptomycin- and Methicillin-Resistant Staphylococcus aureus Under Daptomycin Exposure
Genomic and Long-Term Transcriptomic Imprints Related to the Daptomycin Mechanism of Action Occurring in Daptomycin- and Methicillin-Resistant Staphylococcus aureus Under Daptomycin Exposure
PRJNA498510 | ENA
TranscriptomicsDaptomycin-Resistance Mechanisms in Clinically-Derived Staphylococcus aureus Strains Assessed by a Combined Transcriptomics and Proteomics Approach
Objectives: Development of daptomycin resistance (DAPR) in Staphylococcus aureus is associated with clinical treatment failures. Mechanism(s) of such resistance has not been clearly defined. Methods: We studied an isogenic daptomycin-susceptible (DAPS) and daptomycin-resistant (DAPR) S. aureus stra...
ORGANISM(S): Staphylococcus aureus 
2011-12-02 | E-GEOD-28632 | biostudies-arrayexpress
TranscriptomicsIn vitro transcriptomic comparison of daptomycin-resistant Staphylococcus aureus
Mutants from SG511 and NCTC8325 (wild type isolates) resistant to daptomycin were obtained following serial passage experiments in vitro. Transcriptomic experiments showed alteration in the expression of genes involved in various pathways including general metabolism, cell wall regulon and lipid met...
ORGANISM(S): Staphylococcus aureus subsp. aureus NCTC 8325 Staphylococcus aureus subsp. aureus COL Staphylococcus aureus subsp. aureus MW2 Staphylococcus aureus Staphylococcus aureus subsp. aureus Mu50 Staphylococcus aureus subsp. aureus N315 Staphylococcus aureus subsp. aureus MRSA252 Staphylococcus aureus subsp. aureus MSSA476 Staphylococcus aureus subsp. aureus USA300 
2015-11-01 | GSE50842 | GEO
UnknownChemoenzymatic synthesis of daptomycin analogs active against daptomycin-resistant strains.
Not available
S-EPMC7447621 | biostudies-literature
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