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ProteomicsLoss of Serine/Threonine Protein Phosphatase 6 Severely Impairs Sexual Stage Development in Malaria Parasite Plasmodium berghei
Protein phosphorylation plays a critical role during the development of malaria parasites. Here, we performed a functional analysis of a Plasmodium berghei Ser/Thr protein phosphatase 6 (PbPP6), which was associated with the plasma membrane of macrogametes and ookinetes. Compared with the wild-type ...
ORGANISM(S): Plasmodium berghei ANKA 
2025-06-27 | PXD053412 | Pride
Plasmodium  ser/thr protein phosphatase 6  gametogenesis  ca2+ signaling cascade  pkg 
ProteomicsThe Plasmodium falciparum Nuclear Protein Phosphatase NIF4 is Required for Efficient Merozoite Invasion and Regulates Artemisinin Sensitivity
Artemisinin resistance in Plasmodium falciparum, clinically presented as prolonged parasite clearance half-life, has been associated with a mutation in the NLI-interacting factor-like phosphatase PfNIF4, in addition to the mutations in the Kelch13 protein as the major determinant. We found that PfNI...
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2022-07-23 | PXD033957 | Pride
Malaria  protein phosphatase  invasion  rna polymerase ii  asexual development 
ProteomicsThe Plasmodium falciparum Nuclear Protein Phosphatase NIF4 is Required for Efficient Merozoite Invasion and Regulates Artemisinin Sensitivity
Artemisinin resistance in Plasmodium falciparum, clinically presented as prolonged parasite clearance half-life, has been associated with a mutation in the NLI-interacting factor-like phosphatase PfNIF4, in addition to the mutations in the Kelch13 protein as the major determinant. We found that PfNI...
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2022-07-23 | PXD034167 | Pride
Malaria  protein phosphatase  invasion  rna polymerase ii  asexual development 
ProteomicsA G-protein-coupled receptor modulates gametogenesis via PKG-mediated signaling cascade in Plasmodium berghei
Gametogenesis is essential for malaria parasite transmission, but the molecular mechanism of this process remains to be refined. Here, we identified a G-protein-coupled receptor 180 (GPR180) that plays a critical role in signal transduction during gametogenesis in Plasmodium. In the rodent parasite ...
ORGANISM(S): Plasmodium berghei ANKA 
2022-04-01 | PXD030837 | Pride
Gametogenesis G-protein-coupled receptors Cgmp-pkg- ca2+ signaling cascades Malaria 
ProteomicsThe Plasmodium falciparum Nuclear Protein Phosphatase NIF4 is Required for Efficient Merozoite Invasion and Regulates Artemisinin Sensitivity
Artemisinin resistance in Plasmodium falciparum, clinically presented as prolonged parasite clearance half-life, has been associated with a mutation in the NLI-interacting factor-like phosphatase PfNIF4, in addition to the mutations in the Kelch13 protein as the major determinant. We found that PfNI...
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2022-07-23 | PXD030249 | Pride
Malaria  protein phosphatase  invasion  rna polymerase ii  asexual development 
ProteomicsLoss of Serine/Threonine Protein Phosphatase 6 Severely Impairs Sexual Stage Development in Malaria Parasite Plasmodium berghei
Protein phosphorylation plays a critical role during the development of malaria parasites. Here, we performed a functional analysis of the Plasmodium berghei Ser/Thr protein phosphatase 6 (PbPP6), which was associated with the plasma membrane of macrogametes and ookinetes. Compared to wild-type P. b...
ORGANISM(S): Plasmodium berghei 
2025-06-27 | PXD063164 | Pride
Loss of serine/threonine protein phosphatase 6 severely impairs sexual stage development in malaria parasite plasmodium berghei 
ProteomicsA liquid chromatography-tandem mass spectrometry analysis of endogenous TWIST1 immunoprecipitates in the LSCs from MLL-AF9+ AML mice
We performed a liquid chromatography-tandem mass spectrometry analysis of endogenous TWIST1 immunoprecipitates in the LSCs isolated from MLL-AF9-driven AML mice
ORGANISM(S): Mus Musculus 
2022-10-09 | PXD037217 |
ProteomicsProteins interact with GADD45g in c-kit+ BM cells of wild-type mice
Proteins detected by LC-MS/MS by anti-GADD45g IP in c-kit+ BM cells of wild-type mice.
ORGANISM(S): Mus Musculus 
2023-01-05 | PXD039261 |
ProteomicsAddressing Enzymatic-Independent Tumor-Promoting Function of NAMPT via PROTAC-Mediated Degradation
The rate-limiting enzyme of salvage pathway for NAD+ synthesis, NAMPT, is aberrantly overexpressed in a variety of tumor cells and is a poor prognosis factor for patient survival. NAMPT plays a major role in tumor cell proliferation, acting concurrently as a NAD+ synthase and unexpectedly, an extrac...
ORGANISM(S): Homo Sapiens 
2021-09-13 | PXD028453 |
ProteomicsAddressing Enzymatic-Independent Tumor-Promoting Function of NAMPT via two PROTAC-Mediated Degradation
The rate-limiting enzyme of salvage pathway for NAD+ synthesis, NAMPT, is aberrantly overexpressed in a variety of tumor cells and is a poor prognosis factor for patient survival. NAMPT plays a major role in tumor cell proliferation, acting concurrently as an NAD+ synthase and unexpectedly, an extra...
ORGANISM(S): Homo Sapiens 
2022-01-24 | PXD031185 |
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