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GenomicsGenome-wide chromatin-immunoprecipitation studies of purified SAN cells reveals critical direct targets of ISL1 and suggests potential co-factor families for ISL1 action in SAN cells
Understanding factors that drive development and function of the sinoatrial node (SAN) is crucial to development of potential therapies for sinus arrhythmias, including potential generation of biological pacemakers. Here, we identify a key cell autonomous role for the LIM homeodomain transcription f...
ORGANISM(S): Mus musculus 
2015-07-23 | E-GEOD-68974 | biostudies-arrayexpress
ProteomicsDendrobium mixture ameliorates non-alcoholic fatty liver disease induced by type 2 diabetes mellitus through PPAR gamma: an integrated study of bioinformatics analysis and experimental verification
Dendrobium mixture (DM) is a patented Chinese herbal medicine indicated which has anti inflammatory and improved glycolipid metabolism. However, its active ingredients, targets of action, and potential mechanisms are still uncertain. Here, we investigate the role of DM as a prospective modulator of ...
ORGANISM(S): Mus Musculus 
2023-01-28 | PXD039727 |
ProteomicsArginine GlcNAcylation of Rab small GTPases by the pathogen Salmonella Typhimurium
We determined the GlcNAcyaltion of Rab1 by a Salmonella T3SS effector SseK3. IP experiments were performed from HEK293 cells and MS files were acquired on Q Exactive mass spectrometer. We analysed the differences of protein abundance, comparing the normalized intensity on distinct proteins from diff...
ORGANISM(S): Homo Sapiens Escherichia Coli Mus Musculus 
2020-06-05 | PXD019062 |
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