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TranscriptomicsMYB silencing in CD34+ progenitor cells
The c-Myb transcription factor is highly expressed in immature hematopoietic cells and down-regulated during differentiation. To define the role of c-Myb in human hematopoietic lineage commitment, we studied the effects of its silencing during the commitment of human CD34+ Hematopoietic stem/progeni...
ORGANISM(S): Homo sapiens 
2010-07-14 | E-GEOD-13110 | biostudies-arrayexpress
TranscriptomicsMYB silencing in CD14-myeloblasts
The c-Myb transcription factor is highly expressed in immature hematopoietic cells and down-regulated during differentiation. To define the role of c-Myb during the terminal differentiation of hematopoietic precursors, we studied the effects of its silencing in human primary CD14-myeloblasts, which ...
ORGANISM(S): Homo sapiens 
2010-07-14 | E-GEOD-21943 | biostudies-arrayexpress
TranscriptomicsCo-culture of human hematopoietic stem cells with osteoblasts affects mono/macrophage versus erythroid lineage choice.
Hematopoietic stem cells (HSCs) are located in the bone marrow in a specific microenvironment referred as the hematopoietic stem cell niche, where HSCs interact with a variety of stromal cells. Though several components of the stem cell niche have been identified, the regulatory mechanisms through w...
ORGANISM(S): Homo sapiens 
2013-05-10 | E-GEOD-38091 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human hemopoietic progenitors and myeloid differentiated cells
Differential gene expression profiling of human hemopoietic progenitors and myeloid differentiated cells Experiment Overall Design: We assessed the gene expression in Lin+CD34+, CD14+, CD16+ and CD16- cells.
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-3242 | biostudies-arrayexpress
TranscriptomicsExpression data from untreated and valproic acid (VPA) treated CD34+ Hematopoietic Stem Cells (HSCs)
Histone deacetylase (HDAC) inhibitors are widely utilized in hematopoietic malignance therapy; nevertheless, little is currently known concerning their effects on normal myelopoiesis. In order to investigate a putative interference of HDAC inhibitors in myeloid commitment of hematopoietic stem/proge...
ORGANISM(S): Homo sapiens 
2013-04-11 | E-GEOD-31283 | biostudies-arrayexpress
TranscriptomicsExpression data from untreated and ATP treated AML blasts
In the present study, we investigated whether, and to what extent, P2Rs and their ligands are involved in the regulation of AML cells. Our findings show that AML blasts express several receptors belonging to the P2X and P2Y family. Although different samples respond differently to ATP and UTP stimul...
ORGANISM(S): Homo sapiens 
2012-02-25 | E-GEOD-30903 | biostudies-arrayexpress
TranscriptomicsGene expression profile of mutated and wild-type PMF CD34+ cells
Primary mielofibrosis (PMF) is a rare chronic myeloproliferative disorder characterized by the accumulation of abnormal megakaryocytes (Mks) in the bone marrow (BM), variable degrees of BM fibrosis, osteosclerosis and angiogenesis, immature myeloid and erythroid cells, and tear-drop erythrocytes in ...
ORGANISM(S): Homo sapiens 
2013-07-23 | E-GEOD-41812 | biostudies-arrayexpress
TranscriptomicsIntegrative Analysis of Gene and miRNA expression profiles in Primary Myelofibrosis CD34+ cells
Ph-negative myeloproliferative neoplasms (MPNs) are characterized by many somatic mutations which have already been shown useful in the prognostic assessment of MPN patients. Moreover, aberrant microRNA (miRNA) expression seems to add to the molecular complexity of MPNs, as specific miRNA signatures...
ORGANISM(S): Homo sapiens 
2014-10-01 | E-GEOD-53482 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human CD43+ cells from idiopathic myelofibrosis patients vs normal individuals identifies a set of disease-associated genes and reveals the clinical significance of Wilms tumor gene 1 (WT1)
IM CD34+ vs BM CD34+ cells Experiment Overall Design: Differential gene expression profiling of CD34+ cells purified from the PB of 15 IM patients (3 distinct pools) and from the BM of 15 healthy subjects (3 distinct pools)
ORGANISM(S): Homo sapiens 
2007-11-08 | E-GEOD-3410 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of CD45+/Sca1+ cells isolated from the bone marrow and the muscle
The BM-derived CD45+/Sca1+ cells are haematopoietic stem/progenitor cells that have the ability to circulate and migrate and engraft to the muscle tissue, and therefore they are of particular interest. Notably, these cells retain their haematopoietic potential, as revealed both by in vitro and in vi...
ORGANISM(S): Mus musculus 
2010-04-05 | E-GEOD-9296 | biostudies-arrayexpress
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