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ProteomicsParkin-dependent mitophagy occurs via proteasome-dependent stepwise inwardly directed mitochondrial sub-compartment targeting to lysosomes
PINK1/parkin-dependent mitophagy initially involves (phospho) ubiquitin-proteasome-dependent degradation of certain outer mitochondrial membrane (OMM) proteins (e.g. mitofusins) and then the recruitment of autophagy effectors to more stable ubiquitinated OMM proteins. It is widely assumed that such ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-26 | PXD034136 | Pride
Mitochondrial outer membrane  mitophagy  parkin  proteasome  ubiquitin 
ProteomicsA nanobody-based toolset to monitor and modify the mitochondrial GTPase Miro1
The mitochondrial outer membrane (MOM)-anchored GTPase Miro1, is a central player in mitochondrial transport and homeostasis. The dysregulation of Miro1 in amyotrophic lateral sclerosis (ALS) and Parkinson's disease (PD) suggests that Miro1 may be a potential biomarker or drug target in neuronal dis...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD031218 | Pride
Nanobody Miro1 Interactome 
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