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GenomicsMeCP2 binds to mCH as neurons mature, influencing transcription and onset of Rett syndrome [ChIP-Seq]
The postnatal neurodevelopmental disorder Rett syndrome (RTT) is caused by mutations in the gene encoding Methyl-CpG-binding Protein 2 (MeCP2). Despite decades of research, it remains unclear how MeCP2 actually regulates transcription or why RTT features appear only 6-18 months after birth. We exami...
ORGANISM(S): Mus musculus 
2015-04-15 | E-GEOD-66868 | biostudies-arrayexpress
UnknownFragile X-like behaviors and abnormal cortical dendritic spines in cytoplasmic FMR1-interacting protein 2-mutant mice.
Not available
S-EPMC4355018 | biostudies-literature
TranscriptomicsExpression data from 6 day-old Atxn1L-/- and Atxn1-/- lung tissues
Although expansion of a polyglutamine tract in ATAXIN1 (ATXN1) causes Spinocerebellar ataxia type 1, the functions of wild-type ATXN1 and ATAXIN1-Like (ATXN1L) remain poorly understood. To gain insight into the function of these proteins, we generated and characterized Atxn1L-/- and Atxn1-/- ; Atxn1...
ORGANISM(S): Mus musculus 
2011-11-06 | E-GEOD-29551 | biostudies-arrayexpress
TranscriptomicsCapicua-dependent transcriptional changes in adult mouse cerebellum
Analysis of cerebella from Capicua (Cic) mutant mice and wild-type controls at 28 days of age (P28). Spinocerebellar ataxia type 1 (SCA1) is a fatal neurodegenerative disease caused by expansion of a translated CAG repeat in Ataxin-1 (ATXN1). The transcriptional repressor Cic binds directly to Atxn1...
ORGANISM(S): Mus musculus 
2011-11-07 | E-GEOD-32051 | biostudies-arrayexpress
TranscriptomicsRole of Capicua in metabolic system
CIC is a HMG box-containing transcriptional repressor evolutionarily conserved from C. elegans to human. It's known to associate with various types of cancer but physiological function of CIC remain largely unknown. In this study, we characterized Cic hypomorphic (Cic-L-/-) mice and identified criti...
ORGANISM(S): Mus musculus 
2015-04-15 | E-GEOD-60375 | biostudies-arrayexpress
TranscriptomicsThe Atoh1 targetome in murine postnatal cerebellum
A relatively small number of proneural transcription factors specify a multitude of neural progenitor populations in the developing mammalian brain. Despite their importance, little is known about their targets, cellular processes they regulate, or what genomic sites they occupy in vivo. We used an ...
ORGANISM(S): Mus musculus 
2011-02-08 | E-GEOD-22111 | biostudies-arrayexpress
UnknownDeficiency of Capicua disrupts bile acid homeostasis.
Not available
S-EPMC4317698 | biostudies-literature
UnknownRestoration of Mecp2 expression in GABAergic neurons is sufficient to rescue multiple disease features in a mouse model of Rett syndrome.
Not available
S-EPMC4946897 | biostudies-literature
UnknownAcute MeCP2 loss in adult mice reveals transcriptional and chromatin changes that precede neurological dysfunction and inform pathogenesis.
Not available
S-EPMC11802321 | biostudies-literature
UnknownATXN1 protein family and CIC regulate extracellular matrix remodeling and lung alveolarization.
Not available
S-EPMC3253850 | biostudies-literature
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