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TranscriptomicsLytic infection of Lactococcus lactis by bacteriophages Tuc2009 and c2 trigger alternative transcriptional host responses
This study analysed the temporal transcriptional response of L. lactis UC509.9 undergoing infection with either Tuc2009 or c2, representing phages of two different species (P335 and c2, respectively) of the family Siphoviridae. For the first time, to our knowledge, both DNA microarrays of the host a...
ORGANISM(S): Lactococcus lactis subsp. cremoris UC509.9 
2013-06-27 | E-GEOD-45655 | biostudies-arrayexpress
TranscriptomicsSupervised Lowess normalization of comparative genome hybridization data: application to lactococcal strain comparisons.
Background Array-based comparative genome hybridization (aCGH) is commonly used to determine the genomic content of bacterial strains. In aCGH data, systematic errors are comparable to those occurring in transcriptome data. However, especially for microbes, an additional source of variation exists: ...
ORGANISM(S): Lactococcus lactis subsp. cremoris MG1363 
2008-07-19 | E-GEOD-9039 | biostudies-arrayexpress
TranscriptomicsFunctional genome analysis of Bifidobacterium breve UCC2003 reveals a major conserved host-colonization factor
Development of the human gut microbiota commences at birth with bifidobacteria being among the first colonizers of the sterile newborn gastrointestinal tract. To date the genetic basis of bifidobacterial colonization and persistence remains poorly understood. Transcriptomic analysis of the 2,422,684...
ORGANISM(S): Bifidobacterium breve UCC2003 
2011-07-01 | E-GEOD-27491 | biostudies-arrayexpress
TranscriptomicsIdentification of genes essential for Moraxella catarrhalis growth under iron-limiting conditions using Genomic Array Footprinting (GAF): Expression analysis of directed gene deletion mutants.
Iron-sequestration by the human host is a first line defense against respiratory pathogens like Moraxella catarrhalis, which consequently experiences a period of iron-starvation during colonization and infection. We determined the genetic requirements for M. catarrhalis growth during iron-starvation...
ORGANISM(S): Moraxella catarrhalis BBH18 
2013-06-06 | E-GEOD-41547 | biostudies-arrayexpress
TranscriptomicsIdentification of genes essential for Moraxella catarrhalis growth under iron-limiting conditions using Genomic Array Footprinting (GAF)
Iron-sequestration by the human host is a first line defense against respiratory pathogens like Moraxella catarrhalis, which consequently experiences a period of iron-starvation during colonization and infection. We determined the genetic requirements for M. catarrhalis growth during iron-starvation...
ORGANISM(S): Moraxella catarrhalis BBH18 
2013-06-06 | E-GEOD-41546 | biostudies-arrayexpress
TranscriptomicsDiscovering novel bile protection systems in Bifidobacterium breve UCC2003 through functional genomics
Tolerance of gut commensals to bile salt exposure is an important feature for their survival in and colonization of the intestinal environment. A transcriptomic approach was employed to study the response of Bifidobacterium breve UCC2003 to bile, allowing the identification of a number of bile-induc...
ORGANISM(S): Bifidobacterium breve UCC2003 
2011-12-16 | E-GEOD-31032 | biostudies-arrayexpress
TranscriptomicsA conserved two-component signal transduction system controls the response to phosphate starvation in Bifidobacterium breve UCC2003
This work reports on the identification and molecular characterization of a two-component regulatory system (2CRS), encoded by phoRP in Bifidobacterium breve UCC2003, which controls the response to phosphate (Pi) starvation. The response regulator PhoP was shown to bind to the promoter region of pst...
ORGANISM(S): Bifidobacterium breve UCC2003 
2012-09-06 | E-GEOD-34983 | biostudies-arrayexpress
TranscriptomicsTranscriptional response to protease treatments (kallikrein, papain and chymotrypsin) of Bifidobacterium breve 210B
Members of the serpin (serine protease inhibitor) superfamily have been identified in higher, multicellular eukaryotes, as well as in bacteria, although surveillance of available genome sequences indicates that bacterial serpin-encoding (ser) homologs are not widely distributed. In members of the ge...
ORGANISM(S): Bifidobacterium breve 
2010-05-06 | E-GEOD-20626 | biostudies-arrayexpress
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