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ProteomicsRNA helicase DDX21 mediates nucleotide stress responses
The stress of nucleotide pool reduction regulates transcription in neural crest and melanoma cells. To better understand the molecular response caused by nucleotide stress, we designed a chemical suppressor screen for leflunomide, an inhibitor of dihydroorate dehydrogenase. We found that alterations...
ORGANISM(S): Homo sapiens (Human) 
2020-02-06 | PXD014433 | Pride
A375 Ddx21 Rna 
GenomicsDirect Recruitment of Polycomb Repressive Complex 1 (PRC1) to Chromatin by Core Binding Transcription Factors (ChIP-Seq)
Polycomb repressive complexes (PRCs) play key roles in developmental epigenetic regulation. Yet the mechanisms that target PRCs to specific loci in mammalian cells remain incompletely understood. In this study, we show that Bmi1, a core component of Polycomb Repressive Complex 1 (PRC1), binds direct...
ORGANISM(S): Mus musculus 
2012-02-10 | E-GEOD-33653 | biostudies-arrayexpress
TranscriptomicsRe-specification of myeloid precursors from human pluripotent cells into engraftable multi-lineage progenitors
Human pluripotent stem cells were differentiated into hematopoietic progenitors, which were then re-specified using defined transcription factors to resemble hematopoietic stem cells (HSC) We used microarrays to establish the similarity between converted cells and purified human HSCs. The samples an...
ORGANISM(S): Homo sapiens 
2013-11-01 | E-GEOD-49938 | biostudies-arrayexpress
TranscriptomicsExpression data for Mobilized Peripheral Blood CD34+ cells with Wnt or BMP stimulation
Analysis of mobilized peripheral blood CD34+ cells from a healthy volunteer under erythroid differentiation conditions with and without stimulation to the BMP or Wnt signaling pathways. For erythroid differentiation, expanded CD34+ cells were placed in Stemspan SFEM medium supplemented with 2% pen/s...
ORGANISM(S): Homo sapiens 
2011-10-06 | E-GEOD-26351 | biostudies-arrayexpress
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