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GenomicsRNA helicase DDX21 coordinates transcription and noncoding RNA processing of the ribosomal pathway
DEAD-box RNA helicases are vital for the regulation of various aspects of the RNA life cycle, but the molecular underpinnings of their involvement, particularly in mammalian cells, remain poorly understood. Here we show that the DEAD-box RNA helicase DDX21 can sense transcriptional status of both RN...
ORGANISM(S): Homo sapiens 
2014-11-17 | E-GEOD-56802 | biostudies-arrayexpress
ProteomicsRNA helicase DDX21 mediates nucleotide stress responses
The stress of nucleotide pool reduction regulates transcription in neural crest and melanoma cells. To better understand the molecular response caused by nucleotide stress, we designed a chemical suppressor screen for leflunomide, an inhibitor of dihydroorate dehydrogenase. We found that alterations...
ORGANISM(S): Homo sapiens (Human) 
2020-02-06 | PXD014433 | Pride
A375 Ddx21 Rna 
ProteomicsGlucose dissociates DDX21 dimers to regulate mRNA splicing and promote epidermal differentiation
We discovered that glucose directly bind to DDX21, induced the conformation change of the proteins and inhibit its helicase activity. Glucose also inhibits the dimerization of DDX21, re-localize DDX21 from nucleolus to nucleoplasm and reassemble DDX21 to RNA splicing complex. DDX21 is essential for ...
ORGANISM(S): Homo sapiens (Human) 
2023-01-05 | PXD028561 | Pride
Proximity labeling Ddx21 Splicing Glucose Bioid Epidermal differentiation 
ProteomicsHuman HEK293T Label-free proteomics
DDX21 is an RNA helicase protein with a diverse set of biological functions. Abnormal levels of DDX21 protein has been observed in colorectal and breast cancers as well as in schizophrenic patients, making it a potential therapeutic target. DDX21 can bind and unwind guanine-rich four-stranded struct...
ORGANISM(S): Homo sapiens (Human) 
2019-11-07 | PXD013501 | Pride
Human Hek293t Qexactive Lc-ms/ms 
TranscriptomicsIdentification of C/EBPβ Target Genes in ALK+ Anaplastic Large Cell Lymphoma (ALCL) by Gene Expression Profiling and Chromatin Immunoprecipitation
C/EBPβ (CCAAT enhancer binding protein) is a transcription factor that plays a crucial role in survival and transformation of ALK+ anaplastic large cell lymphoma (ALCL). The aim of this study was to identify the downstream targets of C/EBPβ responsible for ALK-mediated oncogenesis. C/EBPβ was knocke...
ORGANISM(S): Homo sapiens 
2013-07-10 | E-GEOD-23368 | biostudies-arrayexpress
GenomicsRNA helicase DDX21 mediates nucleotide stress responses (iCLIP)
RNA helicase DDX21 mediates nucleotide stress responses (iCLIP)
PRJNA526371 | ENA
GenomicsRNAseq analysis of DDX21-silenced colorectal cancer cell HCT8
RNAseq analysis of DDX21-silenced colorectal cancer cell HCT8
PRJNA765952 | ENA
GenomicsRNA helicase DDX21 mediates nucleotide stress responses (ChIP-Seq)
RNA helicase DDX21 mediates nucleotide stress responses (ChIP-Seq)
PRJNA526366 | ENA
GenomicsRNA helicase DDX21 mediates nucleotide stress responses (PRO-Seq)
RNA helicase DDX21 mediates nucleotide stress responses (PRO-Seq)
PRJNA526369 | ENA
Unknown2B and 3C Proteins of Senecavirus A Antagonize the Antiviral Activity of DDX21 via the Caspase-Dependent Degradation of DDX21.
Not available
S-EPMC9329633 | biostudies-literature
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