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UnknownTuck-KGC: based on tensor decomposition for diabetes knowledge graph completion model integrating Chinese and Western medicine.
The medical knowledge graph is essential for intelligent medical services, encompassing personalized diagnostics, precision therapies, and intelligent consultations, among others. However, medical knowledge graphs frequently suffer from incompleteness, primarily due to the absence of certain entitie...
S-EPMC11888843 | biostudies-literature
UnknownChronic Stress Oppositely Regulates Tonic Inhibition in Thy1-Expressing and Non-expressing Neurons in Amygdala.
Chronic or prolonged exposure to stress ranks among the most important socioenvironmental factors contributing to the development of neuropsychiatric diseases, a process generally associated with loss of inhibitory tone in amygdala. Recent studies have identified distinct neuronal circuits within th...
S-EPMC7180173 | biostudies-literature
UnknownSingle-cell profiling of the pig cecum at various developmental stages.
The gastrointestinal tract is essential for food digestion, nutrient absorption, waste elimination, and microbial defense. Single-cell transcriptome profiling of the intestinal tract has greatly enriched our understanding of cellular diversity, functional heterogeneity, and their importance in intes...
S-EPMC10839672 | biostudies-literature
UnknownR229I substitution from oseltamivir induction in HA1 region significantly increased the fitness of a H7N9 virus bearing NA 292K.
The proportion of human isolates with reduced neuraminidase inhibitors (NAIs) susceptibility in highly pathogenic avian influenza (HPAI) H7N9 virus was high. These drug-resistant strains showed good replication capacity without serious loss of fitness. In the presence of oseltamivir, R229I substitut...
S-EPMC467099 | biostudies-literature
UnknownAged bone marrow macrophages drive systemic aging and age-related dysfunction via extracellular vesicle-mediated induction of paracrine senescence.
The accumulation and systemic propagation of senescent cells contributes to physiological aging and age-related pathology. However, which cell types are most susceptible to the aged milieu and could be responsible for the propagation of senescence has remained unclear. Here we found that physiologic...
S-EPMC11564114 | biostudies-literature
UnknownImpact of high-power short-duration atrial fibrillation ablation technique on the incidence of silent cerebral embolism: a prospective randomized controlled study.

Background

High-power short-duration (HPSD) ablation strategy has emerged as a popular approach for treating atrial fibrillation (AF), with shorter ablation time. The utilized Smart Touch Surround Flow (STSF) catheter, with 56 holes around the electrode, lowers electrode-tissue temperature a...
S-EPMC10666361 | biostudies-literature
UnknownThe microenvironment cell index is a novel indicator for the prognosis and therapeutic regimen selection of cancers.

Background

It is worthwhile to establish a prognostic prediction model based on microenvironment cells (MCs) infiltration and explore new treatment strategies for triple-negative breast cancer (TNBC).

Methods

The xCell algorithm was used to quantify the cellular components of the TNBC...
S-EPMC11727790 | biostudies-literature
UnknownThe Euscaphis japonica genome and the evolution of malvids.
Malvids is one of the largest clades of rosids, includes 58 families and exhibits remarkable morphological and ecological diversity. Here, we report a high-quality chromosome-level genome assembly for Euscaphis japonica, an early-diverging species within malvids. Genome-based phylogenetic analysis s...
S-EPMC9298382 | biostudies-literature
UnknownAssociation of HSP90B1 genetic polymorphisms with efficacy of glucocorticoids and improvement of HRQoL in systemic lupus erythematosus patients from Anhui Province.
Objective: The aim of this study was to investigate the associations between HSP90B1 gene polymorphisms and the efficacy of glucocorticoids (GCs) and the improvement of health-related quality of life (HRQoL) in Anhui patients with systemic lupus erythematosus (SLE). Method: A total of ...
S-EPMC5944816 | biostudies-literature
UnknownAntiviral therapy and outcomes of patients with pneumonia caused by influenza A pandemic (H1N1) virus.

Background

There is limited data on the clinical outcome of patients with pandemic H1N1 (pH1N1) pneumonia who received oseltamivir treatment, especially when the treatment was administered more than 48 hours after symptom onset.

Methods

During the pandemic in 2009, a cohort of pH1N1 i...
S-EPMC3262784 | biostudies-literature
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