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TranscriptomicsA new Rrf2 repressor family member, SaiR, controls transcription of spxA2 encoding a regulator of the oxidative stress response in Bacillus anthracis.
Spx, a member of the ArsC (arsenate reductase) protein family, is highly conserved in Gram-positive bacteria, where it interacts with RNA polymerase to activate transcription in response to toxic oxidants.  In Bacillus anthracis, resistance to oxidative stress requires the activity of two paralogou...
ORGANISM(S): Bacillus anthracis 
2014-05-21 | E-GEOD-57851 | biostudies-arrayexpress
ProteomicsInhibition of CBP synergizes with the RNA-dependent mechanisms of azacitidine by limiting protein translation
The nucleotide analogue azacitidine (AZA) interferes with RNA and DNA metabolism and is currently the best treatment option for a subset of patients with high-risk myelodysplastic syndromes. However, only half of treated patients respond and almost all patients that initially respond eventually rela...
ORGANISM(S): Homo sapiens (Human) 
2021-09-22 | PXD021738 | Pride
Hypomethylating agents  azacitidine  epigenetic regulation  lysine acetyl tranferase inhibitors  creb binding protein / cbp / p300  shrna screen  protein synthesis Clonal hematopoietic disorders Myelodysplastic syndromes  secondary acute myeloid leukemia 
UnknownGlobal economic burden of unmet surgical need for appendicitis.
Not available
S-EPMC10364778 | biostudies-literature
UnknownRisk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.
Not available
S-EPMC6306365 | biostudies-literature
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