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MetabolomicsMethionine Intervention Induces PD-L1 Expression to Enhance the Immune Checkpoint Therapy Response in MTAP-deleted Osteosarcoma
Osteosarcoma (OS), a malignant bone tumor with limited treatment options, exhibits low sensitivity to immune checkpoint therapy (ICT). Through genomics and transcriptomics analyses, we have identified a subgroup of OS with methylthioadenosine phosphorylase (MTAP) deletion, which contributes to ICT r...
2026-06-09 | MTBLS11985 | MetaboLights
UnknownMAVS/CMTM6 axis couples mitochondrial homeostasis to immunogenic senescence via CCL3-driven T-cell recruitment in renal carcinoma.
Not available
S-EPMC12766799 | biostudies-literature
TranscriptomicsGlobal transcriptional analysis of mouse fibroblasts, chemically-induced neurons (neuron-like cells) from mouse fibroblasts and mouse primary cortical neurons by RNA-seq
Recently, direct reprogramming between divergent lineages has been achieved by introducing cell-fate-determining transcription factors. This progress may provide alternative cell resources for drug discovery and regenerative medicine. However, the genetic manipulation may limit the future applicatio...
ORGANISM(S): Mus musculus 
2015-08-12 | E-GEOD-68715 | biostudies-arrayexpress
UnknownEtoposide activates CD8<sup>+</sup> T cell anti-tumor immunity in osteosarcoma through MHC I upregulation via tumor-secreted IL-33 mediated signaling.
Not available
S-EPMC12718598 | biostudies-literature
UnknownA novel immunochemotherapy based on immunogenicity-activated and immunosuppression-reversed biomimetic nanoparticles.
Not available
S-EPMC9527569 | biostudies-literature
UnknownExploration of a Robust and Prognostic Immune Related Gene Signature for Cervical Squamous Cell Carcinoma.
Not available
S-EPMC7967036 | biostudies-literature
UnknownA multimodality score strategy for assessing the risk of immune checkpoint inhibitors related cardiotoxicity.
Not available
S-EPMC11496699 | biostudies-literature
UnknownTau inhibits PKA by nuclear proteasome-dependent PKAR2α elevation with suppressed CREB/GluA1 phosphorylation.
Not available
S-EPMC6974714 | biostudies-literature
UnknownData-driven prediction of colonization outcomes for complex microbial communities.
Not available
S-EPMC10944475 | biostudies-literature
UnknownClassifying Breast Cancer Subtypes Using Multiple Kernel Learning Based on Omics Data.
Not available
S-EPMC6471546 | biostudies-literature
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