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ProteomicsUbiquitin chain editing promotes p97/VCP-dependent removal of RPA from DNA (cross-linking mass spectrometry)
DNA repair requires dynamic control of proteins on single-stranded DNA (ssDNA), yet how ubiquitin signaling regulates ssDNA-bound factors remains poorly understood. Here we identify in human cells a ubiquitin chain editing mechanism that promotes extraction of replication protein A (RPA) from ssDNA....
ORGANISM(S): Homo sapiens (Human) 
2026-09-16 | PXD039482 | Pride
Cross-linking mass spectrometry Dna damage response Ubiquitin signalling 
GenomicsGene expression differences between wild-type and ZUP1 knock-out mice in liver infected with MHV-A59
Gene expression differences between wild-type and ZUP1 knock-out mice in liver infected with MHV-A59
PRJNA1209862 | ENA
TranscriptomicsGene expression differences between wild-type and ZUP1 knock-out mice in liver infected with MHV-A59
To investigate the transcriptome differences between wild-type and ZUP1 knock-out mice in liver when they were infected with MHV, we employed MHV-A59, a hepatic and neuronal tropic murine coronavirus, to infect wild-type and Zup1 knockout mice and colleted liver tissues after MHV infection to perfor...
ORGANISM(S): Mus musculus 
2025-01-16 | GSE286528 | GEO
ProteomicsUbiquitin chain editing promotes p97/VCP-dependent removal of RPA from DNA
DNA repair requires dynamic control of proteins on single-stranded DNA (ssDNA), yet how ubiquitin signaling regulates ssDNA-bound factors remains poorly understood. Here we identify in human cells a ubiquitin chain editing mechanism that promotes extraction of replication protein A (RPA) from ssDNA....
ORGANISM(S): Homo sapiens (Human) 
2026-09-16 | PXD061008 | Pride
Ubiquitin Zup1 P97/vcp Deubiquitinase 
OtherUbiquitin chain editing promotes p97/VCP dependent removal of RPA from DNA
How eukaryotic cells choose which DNA repair pathways to use is incompletely understood, yet these decisions are critical to maintain genome stability. Here, we show how error-free DNA repair is controlled by a ubiquitin-dependent mechanism. Central to this is a multi-component ubiquitin chain editi...
ORGANISM(S): Homo sapiens 
2026-09-16 | GSE289609 | GEO
UnknownA structural basis for the diverse linkage specificities within the ZUFSP deubiquitinase family.
Not available
S-EPMC8776766 | biostudies-literature
UnknownDiscovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability.
Not available
S-EPMC5896202 | biostudies-literature
GenomicsUbiquitin chain editing promotes p97/VCP dependent removal of RPA from DNA
Ubiquitin chain editing promotes p97/VCP dependent removal of RPA from DNA
PRJNA1223807 | ENA
UnknownA family of unconventional deubiquitinases with modular chain specificity determinants.
Not available
S-EPMC5824887 | biostudies-literature
UnknownReactive-site-centric chemoproteomics identifies a distinct class of deubiquitinase enzymes.
Not available
S-EPMC5862848 | biostudies-literature
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