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Recent advances in single-cell proteomics have solved many bottlenecks, such as throughput, sample recovery, and scalability via nano-scale sample handling. In this study, we aimed for a sensitive mass spectrometry analysis capable of handling single cells with a conventional mass spectrometry workf...
ORGANISM(S): Homo sapiens (Human) 
2025-05-28 | PXD048052 | Pride
Through a system-level analysis of non-essential two-component signal transduction systems (TCS) genes in Brucella ovis, we have discovered that deletion of an HWE histidine kinase, BOV_1602, leads to significant increase in resistance to SDS detergent and other anionic or zwitterionic detergents. T...
ORGANISM(S): Brucella ovis 
2024-03-26 | GSE262183 | GEO
A Brucella ovis HWE histidine kinase is important for detergent resistance.
In this study, we assessed the target identification performance of TPP in the presence of a commonly used non-ionic detergent or a zwitterionic detergent using a pan-kinase inhibitor staurosporine, our results showed that the addition of either of these detergents significantly impaired the identif...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD042332 | Pride
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