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Meiosis is a conserved yet evolutionarily varied process that underpins sexual reproduction in eukaryotes. In the malaria parasite Plasmodium, meiosis occurs within the mosquito midgut immediately after fertilisation, as the diploid zygote differentiates into a motile ookinete. Here, we identify the...
ORGANISM(S): Plasmodium berghei ANKA 
2026-04-16 | PXD070965 | Pride
Development of the early embryo is thought to be mainly driven by maternal gene products and post-transcriptional gene regulation. Here, we used metabolic labeling to show that RNA can be transferred by sperm into the embryo. To identify genes with paternal expression in the embryo, we performed cro...
ORGANISM(S): Caenorhabditis elegans 
Active DNA Demethylation Regulates Plant Gamete and Zygote Genome Reprogramming
Eukaryotic cells express several classes of small RNAs that regulate gene expression and ensure genome maintenance. Endogenous siRNAs (endo-siRNAs) and Piwi-interacting RNAs (piRNAs) mainly control gene and transposon expression in the germline, while microRNAs (miRNAs) generally function in post-tr...
ORGANISM(S): Ascaris suum 
Single-cell three dimensional genome structures of rice egg, sperm, and unicellular zygote
Eukaryotic cells express several classes of small RNAs that regulate gene expression and ensure genome maintenance. Endogenous siRNAs (endo-siRNAs) and Piwi-interacting RNAs (piRNAs) mainly control gene and transposon expression in the germline, while microRNAs (miRNAs) generally function in post-tr...
ORGANISM(S): Ascaris suum 
The epigenomes of mammalian sperm and oocytes, characterized by gamete-specific 5-methylcytosine (5mC) patterns, are reprogrammed during early embryogenesis to establish full developmental potential. Previous studies have suggested that the paternal genome is actively demethylated in the zygote whil...
ORGANISM(S): Mus musculus 
Single-cell Hi-C reveals unique chromatin reorganization at oocyte-to-zygote transition
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