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ProteomicsH3K4 methylation-promoted transcriptional memory supports faithful zygotic genome activation and development
Accurately established transcriptional programs are paramount for successful embryonic development. At zygotic genome activation, gene expression is initiated for the first time in the life of an embryo. Pioneer transcription factors present in the embryo are essential for this process, however, the...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2025-11-25 | PXD058937 | Pride
H3k4me3  zygotic genome activation (zga)  epigenetic memory  chromatin  transcriptional memory  transcription  early development  xenopus 
ProteomicsGene expression dynamics before and after zygotic gene activation in Drosophila early embryogenesis
Post-transcriptional gene regulatory mechanisms are fundamental to the determination of gene expression dynamics and especially crucial for the earliest stages of animal development in which transcription is nearly silent. Here we performed high-resolution total RNA-sequencing and quantitative mass ...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2025-09-08 | PXD057383 | Pride
Drosophila mzt development 
ProteomicsGENE EXPRESSION DYNAMICS BEFORE AND AFTER ZYGOTIC GENOME ACTIVATION IN DROSOPHILA EARLY EMBRYOGENESIS
Post-transcriptional gene regulatory mechanisms are fundamental for the determination of gene expression dynamics and especially crucial for the earliest stages of animal development in which transcription is nearly silent. Here we performed high-resolution gene expression level change analysis in D...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2025-09-08 | PXD047784 | Pride
Drosophila Mzt Ubiquitin Rbp 
ProteomicsQuantitative proteomics reveals the dynamic proteome landscape of zebrafish embryos during maternal-to-zygotic transition and its relationship to zygotic genome activation
Upon fertilization, the embryonic genome remains transcriptionally inactive until the mid-blastula transition. Zygotic genome activation (ZGA) of vertebrate embryos has been extensively studied using nucleic acid-based strategies, but proteomics data are still scarce, impeding the full mechanistic u...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) Xenopus laevis (African clawed frog) 
2024-05-01 | PXD036678 | Pride
Zygotic genome activation Zebrafish embryo Maternal-to-zygotic transition Quantitative proteomics 
TranscriptomicsSMAUG is required for zygotic transcription during the maternal-zygotic transition MZT
Microarray analysis of zygotic gene expression in 2-to-3 hour wild-type (wt) and smg mutant embryos. Expression is relative to mature, stage 14 oocytes, which contain the full maternal pool of mRNA. Strictly maternal genes that are not transcribed at the MZT contribute approximately 80% of transc...
ORGANISM(S): Drosophila melanogaster 
2010-06-19 | E-GEOD-13287 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Drosophila embryos shows the zinc finger protein Zelda plays a key role in the maternal to zygotic transition
In all animals, the initial events of embryogenesis are controlled by maternal gene products that are deposited into the developing oocyte. At some point after fertilization, control of embryogenesis is transferred to the zygotic genome in a process called the maternal to zygotic transition (MZT). D...
ORGANISM(S): Drosophila melanogaster 
2008-11-22 | E-GEOD-11231 | biostudies-arrayexpress
TranscriptomicsNanog, SoxB1 and Pou5f1/Oct4 regulate widespread zygotic gene activation during the maternal-to-zygotic transition
Upon fertilization, maternal factors direct development in a transcriptionally silent embryo. At the maternal-to-zygotic transition (MZT), a universal step in animal development, unknown maternal factors trigger zygotic genome activation (ZGA). In zebrafish, ZGA is required for gastrulation and clea...
ORGANISM(S): Danio rerio 
2013-09-22 | E-GEOD-47558 | biostudies-arrayexpress
TranscriptomicsOocyte-expressed Yes-associated Protein (YAP) is a Key Activator of the Early Zygotic Genome in Mouse
We generated maternal and paternal mouse models with Yap1-deletion, and elucidated the function of maternal YAP in zygotic genome activation. RNA sequencing with 2 WT oocyte samples at GV stage, 2 YAP-/- oocyte samples at GV stage, 1 WT embryo samples at 4cell stage, 1 YAP-/- embryo samples at at 4-...
ORGANISM(S): Mus musculus 
2016-02-28 | E-GEOD-74344 | biostudies-arrayexpress
GenomicsHerpesviruses mimic zygotic genome activation to promote viral replication
Herpesviruses mimic zygotic genome activation to promote viral replication
PRJNA1134630 | ENA
GenomicsHerpesviruses mimic zygotic genome activation to promote viral replication
Herpesviruses mimic zygotic genome activation to promote viral replication
PRJNA981526 | ENA
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