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Member, St. Jude Faculty Jewelers For Children Endowed Chair in Genetics and Gene Therapy
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Altered GM1 catabolism affects NMDAR-mediated Ca2+ signaling at ER-PM junctions and increases synaptic spine formation
GM1-ganglioside, an abundant GSL in neuronal membranes, is integral to ER-PM junctions where it interacts with synaptic proteins/receptors and regulates Ca2+ signaling.
ORGANISM(S):
Mus musculus (Mouse)
2024-03-19
|
PXD042994
|
Pride
Membrane contact sites (mcs)
Glycosphingolipids (gsls)
Proteomics
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Neuraminidase 1 regulates neuropathogenesis by governing the cellular state of microglia via modulation of Trem2 sialylation.
Not available
S-EPMC11874873
|
biostudies-literature
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