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UnknownHydroxychloroquine is associated with lower seroconversion upon 17DD-Yellow fever primovaccination in patients with primary Sjogren's syndrome.
The present study aimed at investigating whether the hydroxychloroquine (HCQ) treatment would impact the neutralizing antibody production, viremia levels and the kinetics of serum soluble mediators upon planned 17DD-Yellow Fever (YF) primovaccination (Bio-Manguinhos-FIOCRUZ) of primary Sjögren's syn...
S-EPMC11225917 | biostudies-literature
UnknownGhrelin and glucagon-like peptide-1 according to body adiposity and glucose homeostasis.

Objective

We investigated the biological behavior of ghrelin and glucagon-like peptide-1 (GLP-1) after a standard liquid meal according to body adiposity and glucose homeostasis.

Subjects and methods

This cross-sectional study included 41 individuals (92.7% women; aged 38.3 ± 7.8 year...
S-EPMC10665067 | biostudies-literature
UnknownDe Novo Human Angiotensin-Converting Enzyme 2 Decoy NL-CVX1 Protects Mice From Severe Disease After Severe Acute Respiratory Syndrome Coronavirus 2 Infection.
The emergence of novel variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) underscores the need to investigate alternative approaches to prevent infection and treat patients with coronavirus disease 2019. Here, we report the preclinical efficacy of NL-CVX1, a de novo decoy that ...
S-EPMC10503951 | biostudies-literature
UnknownPrevention of hypertension in patients with pre-hypertension: protocol for the PREVER-prevention trial.

Background

Blood pressure (BP) within pre-hypertensive levels confers higher cardiovascular risk and is an intermediate stage for full hypertension, which develops in an annual rate of 7 out of 100 individuals with 40 to 50 years of age. Non-drug interventions to prevent hypertension have ha...
S-EPMC3059277 | biostudies-literature
UnknownUnprecedented social-ecological impacts of the 2023 extreme drought in the central Amazon.
While the 2023 record-breaking drought led to widespread social-ecological impacts across Amazonia, local impacts of such extreme events are rarely described in detail. Here we leverage a large interdisciplinary data collection related to social and ecological impacts in the Central Amazon. Compound...
S-EPMC12639143 | biostudies-literature
UnknownSymptoms of anxiety and depression in patients with persistent asthma: a cross-sectional analysis of the INSPIRERS studies.

Objectives

Anxiety and depression are relevant comorbidities in asthma, but, in Portugal and Spain, data on this topic are scarce. We assessed, in patients with asthma, the frequency of anxiety and depression using the Hospital Anxiety and Depression Scale (HADS) and the European Quality of ...
S-EPMC10163458 | biostudies-literature
UnknownThe impact of surgical delay on resectability of colorectal cancer: An international prospective cohort study.

Aim

The SARS-CoV-2 pandemic has provided a unique opportunity to explore the impact of surgical delays on cancer resectability. This study aimed to compare resectability for colorectal cancer patients undergoing delayed versus non-delayed surgery.

Methods

This was an international pro...
S-EPMC9322431 | biostudies-literature
UnknownDeath following pulmonary complications of surgery before and during the SARS-CoV-2 pandemic.

Background

This study aimed to determine the impact of pulmonary complications on death after surgery both before and during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic.

Methods

This was a patient-level, comparative analysis of two, international prospect...
S-EPMC10364875 | biostudies-literature
UnknownElliptic anisotropy measurement of the f<sub>0</sub>(980) hadron in proton-lead collisions and evidence for its quark-antiquark composition.
Despite the f0(980) hadron having been discovered half a century ago, the question about its quark content has not been settled: it might be an ordinary quark-antiquark ( qq¯ ) meson, a tetraquark ( qq¯qq¯ ) exotic state, a kaon-antikaon ( KK¯ ) molecule, or a quark-antiquark-gluon ( qq¯g...
S-EPMC12391314 | biostudies-literature
UnknownExtended pharmacological thromboprophylaxis and clinically relevant venous thromboembolism after major abdominal and pelvic surgery: international, prospective, propensity score-weighted cohort study.

Background

There is low-certainty evidence on the impact of extended pharmacological prophylaxis on venous thromboembolism-associated morbidity and mortality. The aim of this study was to determine the efficacy and safety of extended prophylaxis after major abdominopelvic surgery for the pre...
S-EPMC11894929 | biostudies-literature
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