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TranscriptomicsmicroRNA and cancer progression in breast tumors
miRNAs are small non-coding RNAs frequently altered in human malignancies. They regulate protein-coding gene expression by mediating mRNA degradation and/or repressing translation via the association with the 3M-bM-^@M-^Y untranslated region (3M-bM-^@M-^Y UTR) of the mRNAs. Aberrant miRNA expression...
ORGANISM(S): Homo sapiens 
2012-12-16 | E-GEOD-26659 | biostudies-arrayexpress
TranscriptomicsmiR148b is a major coordinator of breast cancer progression in a relapse-associated microRNA signature by targeting ITGA5, ROCK1, PIK3CA, NRAS and CSF1
Breast cancer is often fatal during its metastatic dissemination. To unravel the role of microRNAs (miRs) during malignancy, we analyzed miR expression in 77 primary breast carcinomas and identified 16 relapse-associated miRs that correlate with survival and/or distinguish tumor subtypes in differen...
ORGANISM(S): Homo sapiens 
2012-12-16 | E-GEOD-26666 | biostudies-arrayexpress
TranscriptomicsmiR-148b modulates the expression of multiple genes
To identify which miR-148b targets were involved in tumorigenesis, a microarray analysis was performed for miR-148b over-expressing cells versus controls and 129 (49 up and 80 down) modulated genes were revealed. The effects of miR-148b on cancer progression depend on the direct and indirect regulat...
ORGANISM(S): Homo sapiens 
2012-12-16 | E-GEOD-26662 | biostudies-arrayexpress
TranscriptomicsGenome-wide activity of unliganded Estrogen Receptor alpha in breast cancer cells [RNA-Seq]
ERα is essential for the anti-proliferative response of breast cancer cells not only to estrogen antagonists, but also to estrogen withdrawal by means of aromatase inhibitors. We explored here one of the simplest explanation for this, consisting in the possibility that ERα may have a wide genomic fu...
ORGANISM(S): Homo sapiens 
2014-03-03 | E-GEOD-53532 | biostudies-arrayexpress
GenomicsGenome-wide activity of unliganded Estrogen Receptor alpha in breast cancer cells [ChIP-Seq]
Estrogen Receptor ? (ER?) has central role in hormone-dependent breast cancer and its ligand-induced functions have been extensively characterized. However, evidence exists that ER? has functions which are independent of ligands. In the present work, we investigated the binding of ER? to chromatin i...
ORGANISM(S): Homo sapiens 
2014-03-03 | E-GEOD-53531 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of pre-defined sets of neoplastic tissues
To identify a group of genes, characteristic of a single neoplasia and determinant for the risk to relapse, we have performed gene expression analysis of ductal breast carcinoma samples using Affymetrix oligonucletide microarray (HU133A). Biopses from 60 patients, 30 good prognosis (desease free fro...
ORGANISM(S): Homo sapiens 
2008-11-19 | E-GEOD-9662 | biostudies-arrayexpress
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