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TranscriptomicsSmall bowel adenocarcinoma copy number profiles are more closely related to colorectal than to gastric cancers
Purpose: Small bowel adenocarcinoma (SBA) is a rare cancer and consequently the number of clinical trials has been very limited due to the small numbers of patients. Chemotherapy regimens are currently rather arbitrarily chosen between either a colorectal (CRC) or a gastric cancer (GC) regimen. Chr...
ORGANISM(S): Homo sapiens 
2011-06-13 | E-GEOD-23418 | biostudies-arrayexpress
TranscriptomicsGenomic landscape of metastatic colorectal cancer
Response to drug therapy in individual colorectal cancer (CRC) patients is associated with tumor biology. Here we describe the genomic landscape of tumor samples of a homogeneous well-annotated series of patients with metastatic CRC of two phase III clinical trials, CAIRO and CAIRO2. DNA copy number...
ORGANISM(S): Homo sapiens 
2014-11-14 | E-GEOD-36864 | biostudies-arrayexpress
UnknownAssociations of autozygosity with a broad range of human phenotypes.
In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because reproduction between close relatives is both rare and frequently associated with confoundi...
S-EPMC6823371 | biostudies-literature
UnknownAssessing associations between the AURKA-HMMR-TPX2-TUBG1 functional module and breast cancer risk in BRCA1/2 mutation carriers.
While interplay between BRCA1 and AURKA-RHAMM-TPX2-TUBG1 regulates mammary epithelial polarization, common genetic variation in HMMR (gene product RHAMM) may be associated with risk of breast cancer in BRCA1 mutation carriers. Following on these observations, we further assessed the link between the...
S-EPMC4382299 | biostudies-literature
UnknownDirectional dominance on stature and cognition in diverse human populations.
Homozygosity has long been associated with rare, often devastating, Mendelian disorders, and Darwin was one of the first to recognize that inbreeding reduces evolutionary fitness. However, the effect of the more distant parental relatedness that is common in modern human populations is less well und...
S-EPMC4516141 | biostudies-literature
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