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GenomicsSeminoma and embryonal carcinoma footprints identified by analysis of integrated genome-wide epigenetic and expression profiles of germ cell cancer cell lines (ChIP-seq data).
Background: Germ Cell Cancers (GCC), originating from Primordial Germ Cells /gonocytes, are the most common cancer in young men, subdivided in seminoma (SE) and non-seminoma (NS, stem cell component: embryonal carcinoma (EC)). Somatic mutations are rarely found in GCC. It has been proposed that disr...
ORGANISM(S): Homo sapiens 
2014-06-01 | E-GEOD-56450 | biostudies-arrayexpress
ProteomicsTime-course SILAC proteomics to determine the response to WEE1i in RPE-1 WT vs EIF2A-KO RPE-1 cells
AZD1775 is an ATP-competitive inhibitor of WEE1 protein kinase. Inhibition of WEE1 causes hyperactivation of CDK1 and CDK2, which leads to premature mitosis and DNA replication stress. AZD1775 has been evaluated in patients with relapsed high grade serous ovarian cancer (HGSOC) and has shown promisi...
ORGANISM(S): Homo sapiens (Human) 
2025-10-07 | PXD054741 | Pride
Human ovarian wee1 eif2a hgsoc 
UnknownORANGE: A CRISPR/Cas9-based genome editing toolbox for epitope tagging of endogenous proteins in neurons.
Not available
S-EPMC7176289 | biostudies-literature
UnknownAdaption to glucose limitation is modulated by the pleotropic regulator CcpA, independent of selection pressure strength.
Not available
S-EPMC6327505 | biostudies-literature
UnknownStaphylococcal protein A inhibits complement activation by interfering with IgG hexamer formation.
Not available
S-EPMC7896290 | biostudies-literature
UnknownWEE1 inhibitors trigger GCN2-mediated activation of the integrated stress response.
Not available
S-EPMC12749252 | biostudies-literature
UnknownEquity-specific effects of interventions to promote physical activity among middle-aged and older adults: results from applying a novel equity-specific re-analysis strategy.
Not available
S-EPMC8130354 | biostudies-literature
UnknownThe PROactive instruments to measure physical activity in patients with chronic obstructive pulmonary disease.
Not available
S-EPMC4589432 | biostudies-literature
UnknownA hexamerization-enhanced, Fc-silenced agonistic CD27 antibody amplifies T-cell effector functions as single agent and in combination with PD-1 blockade.
Not available
S-EPMC12289993 | biostudies-literature
UnknownPrediction of long-term recurrent ischemic stroke: the added value of non-contrast CT, CT perfusion, and CT angiography.
Not available
S-EPMC7966192 | biostudies-literature
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