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GenomicsTEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors
The genomic regulatory programs that underlie human organogenesis are poorly understood. Human pancreas development, in particular, has pivotal implications for pancreatic regeneration, cancer, and diabetes. We have now created maps of transcripts, active enhancers, and transcription factor networks...
ORGANISM(S): Homo sapiens 
2015-04-06 | E-MTAB-3061 | biostudies-arrayexpress
GenomicsPancreatic islet epigenomics reveals enhancer clusters that are enriched in Type 2 diabetes risk variants
We combined ChIP-seq of chromatin marks and key islet transcription factor with RNA-seq in human islets to map cis-regulatory networks in this primary tissue. The output of this project provides a reference map to dissect genetic variants that alter the susceptibility for Type 2 diabetes, and assist...
ORGANISM(S): Homo sapiens 
2014-01-01 | E-MTAB-1919 | biostudies-arrayexpress
TranscriptomicsMesenchymal stem cells from myelodysplastic syndromes are functionally and genomically abnormal
Myelodysplastic syndromes (MDS) are a group of clonal disorders of hematopoietic stem cells. Mesenchymal stem cells (MSC) are the progenitors of the Bone Marrow (BM) stroma and have been involved in the physiopathology of MDS. The presence of cytogenetic aberrations on MSC from MDS patients is contr...
ORGANISM(S): Homo sapiens 
2010-05-25 | E-GEOD-10822 | biostudies-arrayexpress
TranscriptomicsHypoxia induces pluripotency in primordial germ cells by HIF1 alpha stabilization and Oct4 deregulation
To study the mechanisms of pluripotency induction, we compared gene expression in pluripotent embryonic germ cells (EGCs) and unipotent primordial germ cells (PGCs). We found 11 genes ≥1.5-fold overexpressed in EGCs. None of the genes identified were Yamanaka's genes, but instead related to glycoly...
ORGANISM(S): Mus musculus 
2014-09-18 | E-GEOD-61472 | biostudies-arrayexpress
UnknownGlobal disparities in surgeons' workloads, academic engagement and rest periods: the on-calL shIft fOr geNEral SurgeonS (LIONESS) study.
Not available
S-EPMC11455666 | biostudies-literature
UnknownGlobal hospital-based disease management of acute diverticulitis: a prospective, international cohort study.
Not available
S-EPMC12512976 | biostudies-literature
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