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MetabolomicsUntargeted LC-MS metabolomic studies of Asteraceae species to discover inhibitors of Leishmania major dihydroorotate dehydrogenase

INTRODUCTION: Interesting data about the family Asteraceae as a new source of Leishmania major dihydroorotate dehydrogenase (LmDHODH) inhibitors are presented. This key macromolecular target for parasites causing neglected diseases catalyzes the fourth reaction of the de novo pyr...

2019-10-14 | MTBLS722 | MetaboLights
UnknownN'-[3-(Hy-droxy-imino)-butan-2-yl-idene]-4-methyl-benzene-1-sulfono-hydrazide.
Not available
S-EPMC3297317 | biostudies-literature
ProteomicsSystemic effects of hemorrhagic snake venom metalloproteinases: untargeted peptidomics to explore the pathodegradome of plasma proteins
In this study we investigated the proteolysis of human plasma proteins by HF3, an hemorrhagic metalloproteinase from B. jararaca venom. For this purpose, approaches for the depletion of the most abundant proteins and for the enrichment of low abundant proteins of human plasma were used to minimize t...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD027997 | Pride
Bothrops  snake venom  hemorrhagic factor 3 (hf3)  human plasma  degradome 
UnknownSurvey on Non-Human Primates and Mosquitoes Does not Provide Evidences of Spillover/Spillback between the Urban and Sylvatic Cycles of Yellow Fever and Zika Viruses Following Severe Outbreaks in Southeast Brazil.
Not available
S-EPMC7232473 | biostudies-literature
UnknownPredictors of venous thromboembolism in COVID-19 patients: results of the COVID-19 Brazilian Registry.
Not available
S-EPMC9156830 | biostudies-literature
UnknownPredicting Aedes aegypti infestation using landscape and thermal features.
Not available
S-EPMC7729962 | biostudies-literature
UnknownAlterations in CD39/CD73 axis of T cells associated with COVID-19 severity.
Not available
S-EPMC9349448 | biostudies-literature
UnknownExploring Mannosylpurines as Copper Chelators and Cholinesterase Inhibitors with Potential for Alzheimer's Disease.
Not available
S-EPMC9864808 | biostudies-literature
UnknownGenetic architecture of congenital hypogonadotropic hypogonadism: insights from analysis of a Portuguese cohort.
Not available
S-EPMC11415827 | biostudies-literature
ProteomicsEarly response of C2C12 myotubes to a sub-cytotoxic dose of hemorrhagic metalloproteinase HF3 from Bothrops jararaca venom
Manifestations of local tissue damage, such as hemorrhage and myonecrosis, are among the most dramatic effects of envenomation by viperid snakes. Snake venom metalloproteinases (SVMPs) of the P-III class are main players of the hemorrhagic effect due to their activities in promoting blood vessel dis...
ORGANISM(S): Mus musculus (Mouse) 
2019-02-25 | PXD011274 | Pride
C2c12 myotubes  hf3  snake venom metalloproteinase  peptidomics  proteomics 
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