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TranscriptomicsInduced genomic rearrangements and chromothripsis by micronucleus-mediated chromosome transfer [850K]
Chromosome segregation errors have been linked to DNA damage and genomic rearrangements. Accumulating evidence has shown that catastrophic genomic rearrangements, like chromothripsis, can result from lagging chromosomes undergoing aberrant DNA replication and DNA damage in micronuclei. Detailed char...
ORGANISM(S): Homo sapiens 
2015-08-13 | E-GEOD-71928 | biostudies-arrayexpress
TranscriptomicsInduced genomic rearrangements and chromothripsis by micronucleus-mediated chromosome transfer [CytoSNP12]
Chromosome segregation errors have been linked to DNA damage and genomic rearrangements. Accumulating evidence has shown that catastrophic genomic rearrangements, like chromothripsis, can result from lagging chromosomes undergoing aberrant DNA replication and DNA damage in micronuclei. Detailed char...
ORGANISM(S): Homo sapiens 
2015-08-13 | E-GEOD-71978 | biostudies-arrayexpress
TranscriptomicsChromothripsis in healthy individuals affects multiple protein-coding genes and can result in severe congenital abnormalities in offspring [case 3]
Chromothripsis represents an extreme class of complex chromosome rearrangements (CCRs) with major effects on chromosomal architecture. Although recent studies have associated chromothripsis with congenital abnormalities, the incidence and pathogenic effects of this phenomenon require further investi...
ORGANISM(S): Homo sapiens 
2015-01-31 | E-GEOD-65453 | biostudies-arrayexpress
TranscriptomicsChromothripsis in healthy individuals affects multiple protein-coding genes and can result in severe congenital abnormalities in offspring [case 1]
Chromothripsis represents an extreme class of complex chromosome rearrangements (CCRs) with major effects on chromosomal architecture. Although recent studies have associated chromothripsis with congenital abnormalities, the incidence and pathogenic effects of this phenomenon require further investi...
ORGANISM(S): Homo sapiens 
2015-01-31 | E-GEOD-65451 | biostudies-arrayexpress
TranscriptomicsChromothripsis in healthy individuals affects multiple protein-coding genes and can result in severe congenital abnormalities in offspring [case 2]
Chromothripsis represents an extreme class of complex chromosome rearrangements (CCRs) with major effects on chromosomal architecture. Although recent studies have associated chromothripsis with congenital abnormalities, the incidence and pathogenic effects of this phenomenon require further investi...
ORGANISM(S): Homo sapiens 
2015-01-31 | E-GEOD-65452 | biostudies-arrayexpress
TranscriptomicsThe genomic and transcriptomic dynamics of treatment-naïve epithelial ovarian cancer
We reveal three-dimensional patterns of tumour growth by exploiting the unique metastasizing patterns of treatment naïve stage IIIC/IV epithelial ovarian cancer. We performed topographic mapping of structural genomic rearrangements, coding mutations, copy number changes and RNA expression in biopsi...
ORGANISM(S): Homo sapiens 
2013-06-05 | E-GEOD-47633 | biostudies-arrayexpress
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