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TranscriptomicsEndosome-associated lc3b mRNA is translated in axons and the protein contributes to endosomal clearance
The primary objective of this project was to identify transcripts in close proximity to endosomes using the APEX-seq approach. To achieve this, we employed SH-SY5Y cells expressing APEX2-NES, APEX2-RAB5A, or 2xFYVE-APEX2 constructs. Biotinylation of RNAs was validated by dot blot, and biotinylated R...
ORGANISM(S): Mus musculus 
2026-09-01 | E-MTAB-15783 | biostudies-arrayexpress
TranscriptomicsSelective transcriptional regulation by Myc in cellular growth control and lymphomagenesis [RNA-Seq]
The c-myc proto-oncogene product, Myc, is a transcription factor that binds thousands of genomic loci. Recent work suggested that rather than up- and down-regulating selected groups of genes, Myc targets all active promoters and enhancers in the genome (a phenomenon termed "invasion") and ...
ORGANISM(S): Mus musculus 
2014-07-07 | E-GEOD-51008 | biostudies-arrayexpress
GenomicsTranscription of mammalian cis-regulatory elements is restrained by actively enforced early termination [ChIP-Seq]
Upon recruitment to active enhancers and promoters, RNA polymerase II (Pol_II) generates short non-coding transcripts of unclear function. The mechanisms that control the length and the amount of ncRNAs generated by cis-regulatory elements are largely unknown. Here, we show that the adapter protein ...
ORGANISM(S): Mus musculus 
2015-11-09 | E-GEOD-66951 | biostudies-arrayexpress
TranscriptomicsTranscription of mammalian cis-regulatory elements is restrained by actively enforced early termination [additional RNA]
Upon recruitment to active enhancers and promoters, RNA polymerase II (Pol_II) generates short non-coding transcripts of unclear function. The mechanisms that control the length and the amount of ncRNAs generated by cis-regulatory elements are largely unknown. Here, we show that the adapter protein ...
ORGANISM(S): Mus musculus 
2015-11-09 | E-GEOD-73021 | biostudies-arrayexpress
TranscriptomicsTranscription of mammalian cis-regulatory elements is restrained by actively enforced early termination [additional 4C]
Upon recruitment to active enhancers and promoters, RNA polymerase II (Pol_II) generates short non-coding transcripts of unclear function. The mechanisms that control the length and the amount of ncRNAs generated by cis-regulatory elements are largely unknown. Here, we show that the adapter protein ...
ORGANISM(S): Mus musculus 
2015-11-09 | E-GEOD-72958 | biostudies-arrayexpress
TranscriptomicsTranscription of mammalian cis-regulatory elements is restrained by actively enforced early termination [4C]
Upon recruitment to active enhancers and promoters, RNA polymerase II (Pol_II) generates short non-coding transcripts of unclear function. The mechanisms that control the length and the amount of ncRNAs generated by cis-regulatory elements are largely unknown. Here, we show that the adapter protein ...
ORGANISM(S): Mus musculus 
2015-11-09 | E-GEOD-66950 | biostudies-arrayexpress
TranscriptomicsTranscription of mammalian cis-regulatory elements is restrained by actively enforced early termination [RNA]
Upon recruitment to active enhancers and promoters, RNA polymerase II (Pol_II) generates short non-coding transcripts of unclear function. The mechanisms that control the length and the amount of ncRNAs generated by cis-regulatory elements are largely unknown. Here, we show that the adapter protein ...
ORGANISM(S): Mus musculus 
2015-11-09 | E-GEOD-66953 | biostudies-arrayexpress
TranscriptomicsTranscription of mammalian cis-regulatory elements is restrained by actively enforced early termination [Hi-C]
Upon recruitment to active enhancers and promoters, RNA polymerase II (Pol_II) generates short non-coding transcripts of unclear function. The mechanisms that control the length and the amount of ncRNAs generated by cis-regulatory elements are largely unknown. Here, we show that the adapter protein ...
ORGANISM(S): Mus musculus 
2015-11-09 | E-GEOD-66952 | biostudies-arrayexpress
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