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Transcriptomic studies revealed that hundreds of mRNAs show differential expression in the brains of sleeping versus awake rats, mice, flies, and sparrows. Although these results have offered clues regarding the molecular consequences of sleep and sleep loss, their functional significance thus far h...
ORGANISM(S): Mus musculus 
MiRNAs have been shown to alter both protein expression and secretion in different cellular contexts. By combining in vitro, in vivo and in silico techniques, we demonstrated that overexpression of pre-miR-1307 reduced the ability of breast cancer cells to induce endothelial cell sprouting and angio...
ORGANISM(S): Homo sapiens (Human) 
2024-12-11 | PXD041087 | Pride
Duchenne muscular dystrophy (DMD) is a lethal X-linked recessive disorder caused by loss of function mutations in the dystrophin gene. There is currently no cure for DMD although various promising approaches are progressing through human clinical trials. Among them, exon-skipping therapy using antis...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD060394 | Pride
In the present study, we investigated whether, and to what extent, P2Rs and their ligands are involved in the regulation of AML cells. Our findings show that AML blasts express several receptors belonging to the P2X and P2Y family. Although different samples respond differently to ATP and UTP stimul...
ORGANISM(S): Homo sapiens 
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