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UnknownOutcomes of urgent gastrointestinal-related procedures in Latin America (LATAM-URG): a prospective multicentre study.

Background

Urgent abdominal operations represent a large proportion of surgical care and are associated with substantial morbidity and mortality. Evidence is scarce from low- and middle-income countries (LMICs), including Latin America (LA). The lack of regionally representative outcomes dat...
S-EPMC12921494 | biostudies-literature
UnknownInborn errors of type I IFN immunity in patients with life-threatening COVID-19.
Clinical outcome upon infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ranges from silent infection to lethal coronavirus disease 2019 (COVID-19). We have found an enrichment in rare variants predicted to be loss-of-function (LOF) at the 13 human loci known to govern Toll-...
S-EPMC7857407 | biostudies-literature
UnknownCharacteristics and predictors of death among 4035 consecutively hospitalized patients with COVID-19 in Spain.

Objectives

To analyse the characteristics and predictors of death in hospitalized patients with coronavirus disease 2019 (COVID-19) in Spain.

Methods

A retrospective observational study was performed of the first consecutive patients hospitalized with COVID-19 confirmed by real-time P...
S-EPMC7399713 | biostudies-literature
UnknownX-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19.
Autosomal inborn errors of type I IFN immunity and autoantibodies against these cytokines underlie at least 10% of critical COVID-19 pneumonia cases. We report very rare, biochemically deleterious X-linked TLR7 variants in 16 unrelated male individuals aged 7 to 71 years (mean: 36.7 years) fr...
S-EPMC8532080 | biostudies-literature
UnknownHigh-flow nasal oxygen in patients with COVID-19-associated acute respiratory failure.

Purpose

Whether the use of high-flow nasal oxygen in adult patients with COVID-19 associated acute respiratory failure improves clinically relevant outcomes remains unclear. We thus sought to assess the effect of high-flow nasal oxygen on ventilator-free days, compared to early initiation of...
S-EPMC7876530 | biostudies-literature
UnknownPredictors of failure with high-flow nasal oxygen therapy in COVID-19 patients with acute respiratory failure: a multicenter observational study.

Purpose

We aimed to describe the use of high-flow nasal oxygen (HFNO) in patients with COVID-19 acute respiratory failure and factors associated with a shift to invasive mechanical ventilation.

Methods

This is a multicenter, observational study from a prospectively collected database ...
S-EPMC7934982 | biostudies-literature
UnknownClinical features, ventilatory management, and outcome of ARDS caused by COVID-19 are similar to other causes of ARDS.

Purpose

The main characteristics of mechanically ventilated ARDS patients affected with COVID-19, and the adherence to lung-protective ventilation strategies are not well known. We describe characteristics and outcomes of confirmed ARDS in COVID-19 patients managed with invasive mechanical v...
S-EPMC7387884 | biostudies-literature
UnknownAwake prone positioning does not reduce the risk of intubation in COVID-19 treated with high-flow nasal oxygen therapy: a multicenter, adjusted cohort study.

Background

Awake prone positioning (awake-PP) in non-intubated coronavirus disease 2019 (COVID-19) patients could avoid endotracheal intubation, reduce the use of critical care resources, and improve survival. We aimed to examine whether the combination of high-flow nasal oxygen therapy (HFN...
S-EPMC7537953 | biostudies-literature
UnknownLack of association between classical HLA genes and asymptomatic SARS-CoV-2 infection.
Human genetic studies of critical COVID-19 pneumonia have revealed the essential role of type I interferon-dependent innate immunity to SARS-CoV-2 infection. Conversely, an association between the HLA-B∗15:01 allele and asymptomatic SARS-CoV-2 infection in unvaccinated individuals was recently repor...
S-EPMC11215417 | biostudies-literature
UnknownStratified analyses refine association between TLR7 rare variants and severe COVID-19.
Despite extensive global research into genetic predisposition for severe COVID-19, knowledge on the role of rare host genetic variants and their relation to other risk factors remains limited. Here, 52 genes with prior etiological evidence were sequenced in 1,772 severe COVID-19 cases and 5,347 popu...
S-EPMC11320601 | biostudies-literature
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