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MetabolomicsLactate-driven lysine lactylation mediates high-level colistin resistance in Salmonella
Intracellular pathogens are particularly refractory to antibiotic eradication, leading to persistent and relapsing infections. However, how intracellular metabolic microenvironments shape antibiotic resistance phenotypes remains poorly understood. Here we delineate a metabolic-regulatory axis wherei...
2026-06-17 | MTBLS14781 | MetaboLights
MetabolomicsProtein lactylation of citrate synthase promotes the AKI–CKD transition by activating the NLRP3 inflammasome.

Interstitial renal inflammation contributes to the transition from acute kidney injury (AKI) to chronic kidney disease (CKD). Recently, protein lactylation modification has emerged as a novel mechanism for mediating chronic organ damage. We investigated lactylated protein profiles and the role of...

2025-06-17 | MTBLS12606 | MetaboLights
MetabolomicsStreptococcus anginosus promotes hepatocellular carcinoma progression and BET inhibitor resistance by inducing BRD4 lactylation

Hepatocellular carcinoma (HCC) is a highly aggressive form of carcinoma with a poor prognosis. Diagnostic markers and potential therapeutic targets for HCC are urgently needed. Here, we demonstrate that fecal microbiota transplantation (FMT) using stool samples from HCC patients significantly pro...

2025-12-05 | MTBLS12398 | MetaboLights
ProteomicsLactylation of Tau in Human Alzheimers Disease Brain
Aggregation of phosphorylated tau is associated with cognitive impairment in Alzheimers disease patients. In AD a metabolic shift due to the Warburg effect results in increased lactate production. Lactate can induce a post-translational modification on proteins that conjugates lactyl groups to lysin...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000095881 | MassIVE
ProteomicsGlobal Profiling of Protein Lactylation Across Subcellular Fractionation Methods in HCT-116
Protein lactylation is a novel post-translational modification (PTM) involved in many important physiological processes such as macrophage polarization, immune regulation and tumour cell growth. However, most studies to date have focused on the function of lactylation on histones, and little is know...
ORGANISM(S): Homo sapiens (Human) 
2024-12-15 | PXD053474 | Pride
Post-translation modification Subcellular fractionation method Lactylation 
ProteomicsQuantification of lactylation in mouse peritoneal macrophages with or without stimulation of VSV by LS-MS/MS
Quantification of lactylation in mouse peritoneal macrophages with or without stimulation of VSV(12h) by LS-MS/MS, And lactylation peptides were enriched by Anti-Lactyllysine antibody conjugated agarose beads (PTM-1404, PTM Bio)
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD042171 | Pride
Vsv Quantification Mouse peritoneal macrophages Lactylation Lc-ms/ms 
ProteomicsGlobal Lactylation Profiling Reveals Lactate-Driven Regulatory Mechanisms Promoting Tumor Progression in Oral Carcinoma
Cancer cells often rely on aerobic glycolysis for metabolism, and lactylation, a newly discovered post-translational modification, significantly impacts molecular processes. This study comprehensively analyzes lactylation's role in oral squamous cell carcinoma (OSCC), providing initial insights into...
ORGANISM(S): Homo sapiens (Human) 
2024-08-23 | PXD047673 | Pride
Human Proteome Oral cancer 
ProteomicsSystematic profiling of lysine lactylation proteome reveals distinct changes in lactylation between the parental AGS cells and cisplatin-resistant AGS cells
Lactate enable to cause a novel post-translational modification, lactylation of proteins. We are interested in exploring whether lactate modulates DNA-damaging agents resistance in the form of lactylation. To gain a global view of DNA-damaging agents resistance-related lactylation, especially Kla of...
ORGANISM(S): Homo sapiens (Human) 
2024-05-09 | PXD050906 | Pride
Lysine lactylation 
ProteomicsToxoplasma gondii; protein posttranslational modification; lactylation; metabolism; function
Toxoplasma gondii, a single-celled protozoan parasite (phylum Apicomplexa) and remains the causative pathogen of one of the most wide-spread infectious diseases, toxoplasmosis. To continuously proliferate in warm-blooded animals, this parasite undergoes repeated cycles of invasion, division and indu...
ORGANISM(S): Toxoplasma gondii 
2024-04-07 | PXD022700 | Pride
Toxoplasma gondii 
ProteomicsA Bioorthogonal Chemical Reporter for the Detection and Identification of Protein Lactylation
L-Lactylation is a recently discovered post-translational modification occurring on histone lysine residues to regulate gene expression. However, the substrate scope of lactylation, especially that in non-histone proteins, remains unknown, largely due to the limitations of current methods for analyz...
ORGANISM(S): Homo sapiens (Human) 
2022-06-23 | PXD033454 | Pride
Chemical reporter Chemical proteomics Lactylation 
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