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ProteomicsIdentification of NCDN-interacting proteins in HeLa cells
This project aims to identify proteins interacting with Neurochondrin (NCDN) in human cells. HeLa cells were transfected with either an empty vector or an NCDN expression construct, followed by mass spectrometry-based proteomic analysis. The study focuses on characterizing the NCDN interactome to pr...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD068384 | Pride
Human ncdn hela cells 
GenomicsTranscriptomics of Neurochondrin (NCDN)-depleted and control U251 glioblastoma cells
Transcriptomics of Neurochondrin (NCDN)-depleted and control U251 glioblastoma cells
PRJNA1278615 | ENA
TranscriptomicsTranscriptomics of Neurochondrin (NCDN)-depleted and control U251 glioblastoma cells
Pre mRNA splicing is orchestrated by the spliceosome; a dynamic and highly regulated ribonucleoprotein complex composed of five small nuclear ribonucleoprotein particles (snRNPs). Despite extensive studies, the biogenesis of snRNPs remains incompletely understood. Here, we identify neurochondrin (NC...
ORGANISM(S): Homo sapiens 
2026-07-11 | GSE299993 | GEO
UnknownMonoallelic and bi-allelic variants in NCDN cause neurodevelopmental delay, intellectual disability, and epilepsy.
Not available
S-EPMC8059333 | biostudies-literature
UnknownA postzygotic de novo NCDN mutation identified in a sporadic FTLD patient results in neurochondrin haploinsufficiency and altered FUS granule dynamics.
Not available
S-EPMC8841087 | biostudies-literature
ProteomicsNeurochondrin Drives Colorectal Cancer Progression by Modulating the PODXL–Ezrin Axis and Mitochondrial Function
Neurochondrin (NCDN) has been recently identified as overexpressed in liver metastatic colorectal cancer (CRC) cells compared to poorly metastatic isogenic counterparts. While its cellular function and role in cancer and CRC remain unknown, patient survival data indicate that elevated NCDN levels ar...
ORGANISM(S): Homo sapiens (Human) 
2026-05-03 | PXD066531 | Pride
UnknownOperant Training for Highly Palatable Food Alters Translating Messenger RNA in Nucleus Accumbens D<sub>2</sub> Neurons and Reveals a Modulatory Role of Ncdn.
Not available
S-EPMC11059129 | biostudies-literature
ProteomicsNeurochondrin Drives Colorectal Cancer Progression by Modulating the PODXL–Ezrin Axis and Mitochondrial Function
Neurochondrin (NCDN) has been recently identified as upregulated in metastatic to liver KM12SM colorectal cancer (CRC) cells in comparison to the poorly metastatic KM12C CRC cells. Furthermore, high levels of NCDN in patients correlate to a worse survival. In this work, using an independent patient ...
ORGANISM(S): Homo sapiens (Human) 
2026-05-03 | PXD061002 | Pride
UnknownIn silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes.
Not available
S-EPMC3707685 | biostudies-literature
ProteomicsNeurochondrin interacts with the SMN protein suggesting a novel mechanism for Spinal Muscular Atrophy pathology.
Spinal Muscular Atrophy (SMA) is an inherited neurodegenerative condition caused by reduction in functional Survival Motor Neurones Protein (SMN). SMN has been implicated in transport of mRNA in neural cells for local translation. We previously identified microtubule-dependant mobile vesicles rich i...
ORGANISM(S): Homo sapiens (Human) 
2018-03-15 | PXD008710 | Pride
Snrnps Neurochondrin Sm proteins Smn Spinal muscular atrophy 
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