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ProteomicsMapping the substrate landscape of protein phosphatase 2A catalytic subunit PPP2CA
Protein phosphatase 2A (PP2A) is an essential Ser/Thr phosphatase that regulates a plethora of cellular processes. PP2A operates as a holoenzyme complex, comprising one each of the scaffolding (A), regulatory (B) and catalytic (C) subunits. PPP2CA is the principal catalytic subunit of the PP2A holoe...
ORGANISM(S): Homo sapiens (Human) 
2024-03-18 | PXD045779 | Pride
Targeted protein degradation Ppp2ca Phosphatase Dtag Phospho-proteomics Phosphorylation Pp2a Kinase Protac Substrate landscape 
GenomicsIdentify the Ppp2ca binding sites in the genome [CUT&TAG]
Identify the Ppp2ca binding sites in the genome [CUT&TAG]
PRJNA1041833 | ENA
GenomicsIdentify the changed genes that are regulated by Ppp2ca [RNA-seq]
Identify the changed genes that are regulated by Ppp2ca [RNA-seq]
PRJNA1041836 | ENA
TranscriptomicsIdentify the changed genes that are regulated by Ppp2ca [RNA-seq]
Ppp2ca is a subunit of PP2A complex, which plays critical roles in variaty of tumors and autoimmune diseases. Deletion of Ppp2ca in mice led to hematopoietic disorders, showing increased myeloid differentiation and decreased lymphoid differentiation. Metabolic analysis indicated that Ppp2ca deficien...
ORGANISM(S): Mus musculus 
2025-11-11 | GSE248148 | GEO
GenomicsIdentify the Ppp2ca binding sites in the genome [CUT&TAG]
Ppp2ca is a subunit of PP2A complex. In addition to functioning through its phosphatase activity, PPP2CA has been demonstrated to form a complex with the INTEGRATOR in the promoter of genes and regulate downstream gene expression at the transcriptional level. We found that Ppp2ca deficiency resulted...
ORGANISM(S): Mus musculus 
2025-11-11 | GSE248147 | GEO
GenomicsIdentify the genomic occupying sites of acetylated H3K27 that are affected by Ppp2ca gene [CUT&RUN]
Identify the genomic occupying sites of acetylated H3K27 that are affected by Ppp2ca gene [CUT&RUN]
PRJNA1041831 | ENA
GenomicsIdentify the genomic occupying sites of acetylated H3K27 that are affected by Ppp2ca gene [CUT&RUN]
Ppp2ca is a subunit of PP2A complex, which plays critical roles in a variaty of tumors. Compared with control, ppp2ca deficient hematopoietic stem cells (HSCs) showed increased myeloid differentiation and decreased lymphoid differentiation. We further found that Ppp2ca deficiency led to global incre...
ORGANISM(S): Mus musculus 
2025-11-11 | GSE248146 | GEO
UnknownPotential Role and Clinical Value of PPP2CA in Hepatocellular Carcinoma.
Not available
S-EPMC8516843 | biostudies-literature
UnknownMapping the substrate landscape of protein phosphatase 2A catalytic subunit PPP2CA.
Not available
S-EPMC10915630 | biostudies-literature
UnknownTriptolide targets PPP2CA/ITGA5 axis to suppress lactate-driven ovarian cancer progression.
Not available
S-EPMC12326723 | biostudies-literature
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