Sort   by:  
 Page size 
TranscriptomicsIdentification of HP1 protein binding sites in Drosophila Kc cells using DamID
Heterochromatin protein HP1 is thought to play key role in chromatin structure and gene regulation. We performed a genome-wide mapping of HP1 target genes in the non-polytenic Drosophila Kc cells by using DamID. This approach is based on the ability of a chromatin protein fused to Escherichia coli D...
ORGANISM(S): Drosophila melanogaster 
2007-07-05 | E-MEXP-864 | biostudies-arrayexpress
TranscriptomicsIdentification of SUUR protein binding sites in Drosophila Kc cells using DamID
Salivary gland polytene chromosomes of Drosophila melanogaster have a reproducible set of intercalary heterochromatin sites, characterized by late DNA replication, underreplicated DNA, breaks and frequent ectopic contacts. The SuUR mutation has been shown to suppress underreplication, and wild-type ...
ORGANISM(S): Drosophila melanogaster 
2007-07-04 | E-MEXP-863 | biostudies-arrayexpress
TranscriptomicsGenome-wide profiling of PRC1 and PRC2 Polycomb chromatin binding in Drosophila
Polycomb group (PcG) proteins maintain transcriptional repression of developmentally important genes and have been implicated in cell proliferation and stem-cell self-renewal. We used a genome-wide approach to map binding patterns of PcG proteins (Pc, esc and Sce) in Drosophila Kc cells. We found th...
ORGANISM(S): Drosophila melanogaster 
2010-06-11 | E-GEOD-4564 | biostudies-arrayexpress
TranscriptomicsThe insulator protein SU(HW) modulates nuclear lamina interactions of the Drosophila genome: DamID
Specific interactions of the genome with the nuclear lamina (NL) are thought to assist chromosome folding inside the nucleus and to contribute to the regulation of gene expression. High-resolution mapping has recently identified hundreds of large, sharply defined lamina-associated domains (LADs) in ...
ORGANISM(S): Drosophila melanogaster 
2011-01-24 | E-GEOD-20311 | biostudies-arrayexpress
TranscriptomicsProtein profiling reveals five principal chromatin types in Drosophila cells
The local protein composition of chromatin is important for the regulation of transcription and other functions. By integrative analysis of genome-wide binding maps of 53 broadly selected chromatin components in Drosophila cells, we show that the genome is segmented into five principal chromatin typ...
ORGANISM(S): Drosophila melanogaster 
2010-10-01 | E-GEOD-22069 | biostudies-arrayexpress
TranscriptomicsHistone H1 binding is restricted by histone variant H3.3 (DamID)
Linker histones are involved in the formation of higher-order chromatin structure. Although linker histones have been implicated in the regulation of specific genes, it still remains unclear what their principal binding determinants are and how their repressive function in vitro can be reconciled wi...
ORGANISM(S): Drosophila melanogaster 
2010-06-21 | E-GEOD-16883 | biostudies-arrayexpress
TranscriptomicsThe Hox gene Abd-B controls stem cell niche function in the Drosophila testis
Stem cells reside in a specialized microenvironment, called niche, which provides essential signals controlling stem cell behavior. Proper niche architecture is a key for normal stem cell function, yet only few upstream regulators are known. Here we report that the Hox transcription factor Abd-B, ac...
ORGANISM(S): Drosophila melanogaster 
2013-12-30 | E-GEOD-53709 | biostudies-arrayexpress
TranscriptomicsA network model of the molecular organization of chromatin in Drosophila
Chromatin governs gene regulation and genome maintenance, yet a substantial fraction of the chromatin proteome is still unexplored. Moreover, a global model of the chromatin protein network is lacking. By screening >100 candidates we identify 42 Drosophila proteins that were not previously associate...
ORGANISM(S): Drosophila melanogaster 
2013-02-12 | E-GEOD-36175 | biostudies-arrayexpress
GenomicsIdentifying targets of DSX with DamID-seq
We have adapted the DamID protocol for use with high throughput sequencing. We have used DamID to identify the positions within the Drosophila genome where the transcription factor DSX is bound. We sequenced DpnI-digested genomic DNA from fly tissues containing UAS-Dam (control) or UAS-Dam-DsxF or ...
ORGANISM(S): Drosophila melanogaster 
2014-10-30 | E-GEOD-27269 | biostudies-arrayexpress
UnknownImpacts of Dam Age on Lifetime Productivity of Angus Replacement Beef Females.
Not available
S-EPMC9597753 | biostudies-literature
Sort   by:  
 Page size