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UnknownImpact of a Chronic Total Coronary Occlusion on the Incidence of Appropriate Implantable Cardioverter-Defibrillator Shocks and Mortality: A Substudy of the Dutch Outcome in ICD Therapy (DO-IT)) Registry.

Background

Chronic total coronary occlusions (CTO) substantially increase the risk for sudden cardiac death. Among patients with chronic ischemic heart disease at risk for sudden cardiac death, an implantable cardioverter defibrillator (ICD) is the favored therapy for primary prevention of s...
S-EPMC11262490 | biostudies-literature
TranscriptomicsTranscription profiling of human CALM-AF10 positive and negative T-ALL samples
Comparison of a series of 6 CALM-AF10 positive T-ALL to a series of 17 CALM-AF10 negative T-ALL
ORGANISM(S): Homo sapiens 
2007-08-30 | E-GEOD-2117 | biostudies-arrayexpress
UnknownSex Differences in Revascularization, Treatment Goals, and Outcomes of Patients With Chronic Coronary Disease: Insights From the ISCHEMIA Trial.

Background

Women with chronic coronary disease are generally older than men and have more comorbidities but less atherosclerosis. We explored sex differences in revascularization, guideline-directed medical therapy, and outcomes among patients with chronic coronary disease with ischemia on s...
S-EPMC10944079 | biostudies-literature
UnknownHealth Status after Invasive or Conservative Care in Coronary and Advanced Kidney Disease.

Background

In the ISCHEMIA-CKD trial, the primary analysis showed no significant difference in the risk of death or myocardial infarction with initial angiography and revascularization plus guideline-based medical therapy (invasive strategy) as compared with guideline-based medical therapy a...
S-EPMC7255621 | biostudies-literature
UnknownIdentification of 371 genetic variants for age at first sex and birth linked to externalising behaviour.
Age at first sexual intercourse and age at first birth have implications for health and evolutionary fitness. In this genome-wide association study (age at first sexual intercourse, N = 387,338; age at first birth, N = 542,901), we identify 371 single-nucleotide polymorphisms, 11 sex-specific, with ...
S-EPMC7612120 | biostudies-literature
UnknownA principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape.
Large consortia have revealed hundreds of genetic loci associated with anthropometric traits, one trait at a time. We examined whether genetic variants affect body shape as a composite phenotype that is represented by a combination of anthropometric traits. We developed an approach that calculates a...
S-EPMC5114527 | biostudies-literature
UnknownErratum: Genetic loci associated with heart rate variability and their effects on cardiac disease risk.
This corrects the article DOI: 10.1038/ncomms15805.
S-EPMC5543301 | biostudies-literature
UnknownGenetic loci associated with heart rate variability and their effects on cardiac disease risk.
Reduced cardiac vagal control reflected in low heart rate variability (HRV) is associated with greater risks for cardiac morbidity and mortality. In two-stage meta-analyses of genome-wide association studies for three HRV traits in up to 53,174 individuals of European ancestry, we detect 17 genome-w...
S-EPMC5474732 | biostudies-literature
UnknownGenome-wide association study of circulating interleukin 6 levels identifies novel loci.
Interleukin 6 (IL-6) is a multifunctional cytokine with both pro- and anti-inflammatory properties with a heritability estimate of up to 61%. The circulating levels of IL-6 in blood have been associated with an increased risk of complex disease pathogenesis. We conducted a two-staged, discovery and ...
S-EPMC8098112 | biostudies-literature
UnknownEffect of radiotherapy after mastectomy and axillary surgery on 10-year recurrence and 20-year breast cancer mortality: meta-analysis of individual patient data for 8135 women in 22 randomised trials.

Background

Postmastectomy radiotherapy was shown in previous meta-analyses to reduce the risks of both recurrence and breast cancer mortality in all women with node-positive disease considered together. However, the benefit in women with only one to three positive lymph nodes is uncertain. W...
S-EPMC5015598 | biostudies-literature
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