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TranscriptomicsOncogenomic analysis of mycosis fungoides reveals major differences with Sézary syndrome
Mycosis fungoides (MF), the most common cutaneous T-cell lymphoma (CTCL), is a malignancy of mature, skin-homing T cells. Sézary syndrome (Sz) is often considered to represent a leukemic phase of MF. In this study the pattern of numerical chromosomal alterations in MF tumor samples was defined usin...
ORGANISM(S): Homo sapiens 
2008-09-29 | E-GEOD-12902 | biostudies-arrayexpress
TranscriptomicsNovel and highly recurrent chromosomal alterations in Sézary syndrome
This study was designed to identify highly recurrent genetic alterations typical of Sézary syndrome (Sz), an aggressive cutaneous T-cell lymphoma/leukemia, possibly revealing pathogenetic mechanisms and novel therapeutic targets. High-resolution array-based comparative genomic hybridization was don...
ORGANISM(S): Homo sapiens 
2010-05-18 | E-GEOD-16384 | biostudies-arrayexpress
TranscriptomicsComparison of senescence bypass
Analysis of BRAFE600 induced senescence bypassing cells due to C/EBPbeta or TSC22D1 depletion, compared to BRAFE600 senescent cells.
ORGANISM(S): Homo sapiens 
2011-11-05 | E-MTAB-441 | biostudies-arrayexpress
TranscriptomicsGenome-wide promoter methylation analysis identifies epigenetic silencing of MAPK13 in primary cutaneous melanoma
The implication of epigenetic alterations in the pathogenesis of melanoma is increasingly recognized. Here we performed genome-wide DNA methylation analysis of primary cutaneous melanoma and benign melanocytic naevus interrogating 14,495 genes using beadchip technology. This first genome-wide view o...
ORGANISM(S): Homo sapiens 
2013-04-24 | E-GEOD-45266 | biostudies-arrayexpress
TranscriptomicsPro-invasion metastasis drivers in early stage melanoma are oncogenes
Clinical and genomic evidence support the view that the metastatic potential of a primary tumor may be dictated by transforming events acquired early in the tumorigenic process. It has been proposed that the presence of such pro-metastatic events in early-stage tumors reflects their additional capa...
ORGANISM(S): Mus musculus 
2011-07-11 | E-GEOD-29074 | biostudies-arrayexpress
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