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TranscriptomicsDNA copy number changes in colorectal flat adenomas
Background & aim: Flat adenomas form a specific phenotype of colorectal adenomas that has been associated with more severe molecular changes and consequently a more aggressive clinical behavior compared to their polypoid counterparts. In the present study we set out to compare one of the molecular c...
ORGANISM(S): Homo sapiens 
2012-10-04 | E-GEOD-30479 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human CT116 cells and isogenic genetic knockouts rveals identity of the human cancer cell DNA hypermethylome
Altered gene expression is a hallmark of human cancers and arises in part through abnormal epigenetic regulation of gene transcription. The best characterized epigenetic alteration involves tumor suppressor gene inactivation via transcriptional repression associated with aberrant DNA hypermethylatio...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-4763 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human tumor-conditioned versus quiescent HUVEC cells, and 5-aza-2a??-deoxycytidine and trichostatin AI treated cells to identify epigenetically silenced genes
Tumor angiogenesis requires intricate regulation of gene expression in endothelial cells (EC). We recently showed that DNA methyltransferase (DNMT)- and histone deacetylase (HDAC) inhibitors directly repress EC growth and tumor angiogenesis, suggesting that epigenetic modifications mediated by DNMTs...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7132 | biostudies-arrayexpress
TranscriptomicsIdentifying functional CpG island methylation markers in clear cell renal cell cancer cell lines
Clear cell renal cell carcinoma (ccRCC) is the most common adult renal cancer. Although the molecular characteristics of ccRCC are currently being studied, the biologically and clinically relevant ccRCC methylome remains to be elucidated. To explore the RCC hypermethylome we employed massive sequenc...
ORGANISM(S): Homo sapiens 
2013-11-22 | E-GEOD-33916 | biostudies-arrayexpress
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