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ProteomicsPharmacological CLK inhibition disrupts SR protein function and RNA splicing blocking cell growth and migration in TNBC
Triple-negative breast cancer (TNBC) represents the most aggressive subtype of breast cancer, characterized by a lack of therapeutic options. Dysregulation of alternative splicing plays a pivotal role in tumorigenesis and metastasis. Serine/arginine-rich (SR) proteins, essential components of the sp...
ORGANISM(S): Homo sapiens (Human) 
2025-08-04 | PXD058273 | Pride
Triple-negative breast cancer  alternative splicing  cdc2-like kinase inhibitor  serine/arginine-rich proteins 
ProteomicsCFAP20 accelerates RNAPII elongation from promoters to prevent conflicts with co-directional replisomes
Fine-tuning the coexistence of DNA replication and transcription is essential to avoid detrimental collisions between these two machineries. This is particularly relevant at promoters, as RNA polymerase II (RNAPII) elongation is slowest there, and DNA replication evolutionarily initiates in close pr...
ORGANISM(S): Homo sapiens (Human) 
2026-03-02 | PXD051449 | Pride
Mediator Transcription-replication conflicts Cfap20 
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