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ProteomicsCFAP20 accelerates RNAPII elongation from promoters to prevent conflicts with co-directional replisomes
Fine-tuning the coexistence of DNA replication and transcription is essential to avoid detrimental collisions between these two machineries. This is particularly relevant at promoters, as RNA polymerase II (RNAPII) elongation is slowest there, and DNA replication evolutionarily initiates in close pr...
ORGANISM(S): Homo sapiens (Human) 
2026-03-02 | PXD051449 | Pride
Mediator Transcription-replication conflicts Cfap20 
GenomicsNuclear functions of CFAP20 in transcription and replication [ChIP-seq TY-CFAP20]
Nuclear functions of CFAP20 in transcription and replication [ChIP-seq TY-CFAP20]
PRJNA1267042 | ENA
GenomicsNuclear functions of CFAP20 in transcription and replication [FLASH-seq]
Nuclear functions of CFAP20 in transcription and replication [FLASH-seq]
PRJNA1107614 | ENA
GenomicsNuclear functions of CFAP20 in transcription and replication [BrU-seq]
Nuclear functions of CFAP20 in transcription and replication [BrU-seq]
PRJNA1107610 | ENA
GenomicsNuclear functions of CFAP20 in transcription and replication [ChIP-seq]
Nuclear functions of CFAP20 in transcription and replication [ChIP-seq]
PRJNA1107612 | ENA
GenomicsNuclear functions of CFAP20 in transcription and replication [DRIP-seq]
Nuclear functions of CFAP20 in transcription and replication [DRIP-seq]
PRJNA1107611 | ENA
GenomicsCFAP20 salvages arrested RNAPII from the path of co-directional replisomes
CFAP20 salvages arrested RNAPII from the path of co-directional replisomes
PRJNA1157900 | ENA
UnknownCFAP20 salvages arrested RNAPII from the path of co-directional replisomes.
Not available
S-EPMC12935552 | biostudies-literature
GenomicsNuclear functions of CFAP20 in transcription and replication [TTchem-DRB-seq]
Nuclear functions of CFAP20 in transcription and replication [TTchem-DRB-seq]
PRJNA1107613 | ENA
GenomicsNuclear functions of CFAP20 in transcription and replication [ChIP-seq TY-CFAP20]
Fine-tuning DNA replication and transcription is crucial to prevent collisions between their machineries. This is particularly important near promoters, where RNA polymerase II (RNAPII) initiates transcription and frequently arrests, forming R-loops. Arrested RNAPII can obstruct DNA replication, whi...
ORGANISM(S): Homo sapiens 
2025-05-28 | GSE297966 | GEO
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