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TranscriptomicsAmino acid deprivation due to overexpression of UCP1 in skeletal muscle: signalling via FGF-21
Recent studies on mouse and human skeletal muscle (SM) demonstrated the important link between mitochondrial function and the cellular metabolic adaptation. To identify key compensatory molecular mechanisms in response to chronic mitochondrial distress, we analyzed mice with ectopic SM respiratory u...
ORGANISM(S): Mus musculus 
2015-02-17 | E-GEOD-45991 | biostudies-arrayexpress
TranscriptomicsQuercetin decreases high-fat diet induced bodyweight gain and accumulation of hepatic and circulating lipids in mice.
Dietary flavonoids are supposed to be protective against cardiovascular diseases (CVD). Elevated circulating lipid levels and hepatic lipid accumulation are known risk factors for CVD. We investigated the effects and underlying molecular mechanisms of the flavonoid quercetin on hepatic lipid metabol...
ORGANISM(S): Mus musculus 
2014-10-14 | E-GEOD-51343 | biostudies-arrayexpress
TranscriptomicsQuercetin induces hepatic lipid omega-oxidation and lowers serum lipid levels in mice
Elevated circulating lipid levels are known risk factors for cardiovascular diseases (CVD). In order to examine the effects of quercetin on hepatic lipid metabolism and detailed serum lipid profiles, mice received a mild-high-fat diet without (control) or with supplementation of 0.33% (w/w) querceti...
ORGANISM(S): Mus musculus 
2013-02-05 | E-GEOD-39140 | biostudies-arrayexpress
TranscriptomicsThe effects of ectopic UCP1 expression on gene expression in skeletal muscle
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2015-02-19 | E-GEOD-45993 | biostudies-arrayexpress
TranscriptomicsMuscle Involvement in Preservation of Metabolic Flexibility by Treatment using n-3 PUFA, Rosiglitazone, and a combination of both
This SuperSeries is composed of the following subset Series: GSE36716: Muscle Involvement in Preservation of Metabolic Flexibility by Treatment using n-3 PUFA or Rosiglitazone in Dietary-Obese Mice GSE36717: Muscle Involvement in Preservation of Metabolic Flexibility by a Combination Treatment using...
ORGANISM(S): Mus musculus 
2012-09-07 | E-GEOD-36718 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human lymphocytes from healthy individuals given selenium supplements
The effects of selenium supplementation to healthy individuals using a microarray approach.
ORGANISM(S): Homo sapiens 
2007-12-10 | E-MEXP-1046 | biostudies-arrayexpress
TranscriptomicsMuscle Involvement in Preservation of Metabolic Flexibility by a Combination Treatment using n-3 PUFA and Rosiglitazone in Dietary-Obese Mice
Impaired resistance to insulin, the key defect in type 2 diabetes (T2D), is associated with a low capacity to adapt fuel oxidation to fuel availability, i.e., metabolic inflexibility. The hampered metabolic adaptability triggers a further damage of insulin signaling. Since skeletal muscle is the mai...
ORGANISM(S): Mus musculus 
2012-09-07 | E-GEOD-36717 | biostudies-arrayexpress
TranscriptomicsMuscle Involvement in Preservation of Metabolic Flexibility by Treatment using n-3 PUFA or Rosiglitazone in Dietary-Obese Mice
Impaired resistance to insulin, the key defect in type 2 diabetes (T2D), is associated with a low capacity to adapt fuel oxidation to fuel availability, i.e., metabolic inflexibility. The hampered metabolic adaptability triggers a further damage of insulin signaling. Since skeletal muscle is the mai...
ORGANISM(S): Mus musculus 
2012-09-07 | E-GEOD-36716 | biostudies-arrayexpress
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