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GenomicsGenome-wide analysis of histone eviction by FAIRE-Seq
A major class of chemotherapeutics targets topoisomerase II for DNA double-strand breaks and cancer cell elimination. We compare four members of this class?the anthracyclines doxorubicin, daunorubicin and aclarubicin that does not induce DNA breaks?and a different compound, etoposide. We define a no...
ORGANISM(S): Mus musculus 
2013-06-04 | E-GEOD-33632 | biostudies-arrayexpress
TranscriptomicsTissue selective effects of topoisomerase II inhibitors in vivo
One major class of anti-cancer drugs targets topoisomerase II to induce DNA double-strand breaks and cell death of fast growing cells. In vitro experiments showed that doxorubicin can induce histone eviction as well as DNA damage, while etoposide can only induce DNA damage. Here, we compare the tran...
ORGANISM(S): Mus musculus 
2013-06-04 | E-GEOD-33626 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Brca1- and p53-deficient mouse mammary tumors to treatment with doxorubicin, docetaxel or cisplatin
We have studied in vivo responses of spontaneous Brca1- and p53-deficient mouse mammary tumors to treatment with doxorubicin, docetaxel or cisplatin.
ORGANISM(S): Mus musculus 
2007-06-18 | E-NCMF-5 | biostudies-arrayexpress
TranscriptomicsCrizotinib inhibits metabolic inactivation of gemcitabine in ortothopic pancreatic tumors derived from primary cells with c-Met overexpression
Pancreatic ductal adenocarcinoma (PDAC) remains a major unsolved health problem. Most drugs that pass preclinical tests fail in these patients, emphasizing the need of appropriate preclinical models to test novel anticancer strategies. We developed four orthotopic mouse models employing primary huma...
ORGANISM(S): Homo sapiens 
2013-08-30 | E-GEOD-44587 | biostudies-arrayexpress
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