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GenomicsPatterns and mechanisms of ancestral histone protein inheritance in budding yeast
It is widely believed that chromatin, the nucleoprotein packaging state of eukaryotic genomes, can carry epigenetic information to propagate gene expression patterns in replicating cells. However, inheritance of genomic packaging status is subject to mechanistic challenges that do not confront the i...
ORGANISM(S): Saccharomyces cerevisiae 
2011-10-06 | E-GEOD-28269 | biostudies-arrayexpress
TranscriptomicsExpression profiles of the NuB4/HAT-B complex and histone knockouts
Dynamic modification of histone proteins plays a key role in regulating gene expression. However, histones themselves can also be dynamic, which potentially affects the stability of histone modifications. To determine the molecular mechanisms of histone turnover we developed a parallel screening met...
ORGANISM(S): Saccharomyces cerevisiae 
2012-05-14 | E-GEOD-30168 | biostudies-arrayexpress
TranscriptomicsA network model of the molecular organization of chromatin in Drosophila
Chromatin governs gene regulation and genome maintenance, yet a substantial fraction of the chromatin proteome is still unexplored. Moreover, a global model of the chromatin protein network is lacking. By screening >100 candidates we identify 42 Drosophila proteins that were not previously associate...
ORGANISM(S): Drosophila melanogaster 
2013-02-12 | E-GEOD-36175 | biostudies-arrayexpress
TranscriptomicsA Key Role for Chd1 in Histone H3 Dynamics at the 3' Ends of Long Genes in Yeast (Rpb3 to input)
Chd proteins are ATP-dependent chromatin remodeling enzymes implicated in biological functions from transcriptional elongation to control of pluripotency. Here, we examine roles of Chd1 in replication- independent dynamics of histone H3 in yeast. Using genome-wide ChIP on chip analysis, we find tha...
ORGANISM(S): Saccharomyces cerevisiae 
2012-06-07 | E-GEOD-38493 | biostudies-arrayexpress
TranscriptomicsA Key Role for Chd1 in Histone H3 Dynamics at the 3' Ends of Long Genes in Yeast (H3K4me3 or H3K36me3 to input)
Chd proteins are ATP-dependent chromatin remodeling enzymes implicated in biological functions from transcriptional elongation to control of pluripotency. Here, we examine roles of Chd1 in replication- independent dynamics of histone H3 in yeast. Using genome-wide ChIP on chip analysis, we find tha...
ORGANISM(S): Saccharomyces cerevisiae 
2012-06-07 | E-GEOD-38492 | biostudies-arrayexpress
TranscriptomicsA Key Role for Chd1 in Histone H3 Dynamics at the 3' Ends of Long Genes in Yeast (Flag-tagged histone H3 to total histone H3)
Chd proteins are ATP-dependent chromatin remodeling enzymes implicated in biological functions from transcriptional elongation to control of pluripotency. Here, we examine roles of Chd1 in replication- independent dynamics of histone H3 in yeast. Using genome-wide ChIP on chip analysis, we find tha...
ORGANISM(S): Saccharomyces cerevisiae 
2012-06-07 | E-GEOD-38491 | biostudies-arrayexpress
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