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MetabolomicsMacrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques
Macrophages represent a major immune cell population in atherosclerotic plaques and play central role in the progression of this lipid-driven chronic inflammatory disease. Targeting immunometabolism is proposed as a strategy to revert aberrant macrophage activation to improve disease outcome. Here, ...
2021-03-05 | MTBLS2159 | MetaboLights
ProteomicsProtein aggregation is an early manifestation of phospholamban p.(Arg14del)-related cardiomyopathy
Background: The p.(Arg14del) pathogenic variant (R14del) of the phospholamban (PLN) gene is a prevalent cause of cardiomyopathy with heart failure. The exact underlying pathophysiology is unknown, and a suitable therapy is unavailable. We aim to identify molecular perturbations underlying this cardi...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-03 | PXD024594 | Pride
Inherited cardiomyopathy Heart failure Phospholamban Protein aggregation 
TranscriptomicsTranscription profiling by array of human Caco-2 cells with ATP8B1 knock down
To gain insights whether and if activation of the nuclear receptor FXR is involved in the disease ethiology of ATP8B1 deficiency, we contstructed a Caco-2 ATP8B1 knock down cell line and a Caco-2 empty vector control cell line. Furthermore we expect to gain new insights from transcriptional profilin...
ORGANISM(S): Homo sapiens 
2010-12-31 | E-TABM-989 | biostudies-arrayexpress
MetabolomicsCysteamine-bicalutamide combination therapy corrects proximal tubule phenotype in cystinosis
Nephropathic cystinosis is a severe monogenic kidney disorder caused by mutations in CTNS, encoding the lysosomal transporter cystinosin, resulting in lysosomal cystine accumulation. The sole treatment, cysteamine, slows down the disease progression, but does not correct the established renal proxim...
2021-06-24 | MTBLS2538 | MetaboLights
UnknownS-glutathiolation impairs phosphoregulation and function of cardiac myosin-binding protein C in human heart failure.
Not available
S-EPMC4836368 | biostudies-literature
MetabolomicsMulti-country metabolic signature discovery for chicken health classification

INTRODUCTION: To decrease antibiotic resistance, their use as growth promoters in the agricultural sector has been largely abandoned. This may lead to decreased health due to infectious disease or microbiome changes leading to gut inflammation.

OBJECTIVES: ...

2023-08-08 | MTBLS5065 | MetaboLights
ProteomicsEnzymatic activation of the nitrogen atom in peptide bonds
Abstract The peptide bond is the defining feature of proteins, it co ntrols their structure by enforcing planarity and governs their chemistry by abolishing nucleophili city. This behaviour results from the delocalisation of the lone pair of electrons on the ni...
ORGANISM(S): Escherichia coli 
2020-03-20 | PXD005934 | Pride
Amide chemistry and biochemistry Methylation Enzyme catalysis 
UnknownProtein Aggregation Is an Early Manifestation of Phospholamban p.(Arg14del)-Related Cardiomyopathy: Development of PLN-R14del-Related Cardiomyopathy.
Not available
S-EPMC8589082 | biostudies-literature
UnknownThe phospholamban p.(Arg14del) pathogenic variant leads to cardiomyopathy with heart failure and is unreponsive to standard heart failure therapy.
Not available
S-EPMC7300032 | biostudies-literature
UnknownPCA denoising and Wiener deconvolution of 31 P 3D CSI data to enhance effective SNR and improve point spread function.
Not available
S-EPMC7986807 | biostudies-literature
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