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MetabolomicsAn Atlas of Ferroptosis-induced Secretomes promotes Macrophage priming
Cells undergoing regulated necrosis systemically communicate with the immune system via release of protein and non-protein secretomes. Ferroptosis is a recently described iron-dependent type of regulated necrosis driven by massive lipid peroxidation. While membrane rupture occurs during ferroptosis,...
2025-03-04 | MTBLS9798 | MetaboLights
ProteomicsSecretome analysis of ferroptotic Pfa1 cells
Pfa1 cells undergo ferroptosis upon induction of knockout of the glutathione peroxidase 4 via tamoxifen treatment. Ferroptosis is a recently discovered, iron-dependent mode of cell death, whose potency to evoke an immune response in the surrounding tissue remains to be clarified. The goal of this pr...
ORGANISM(S): Mus musculus (Mouse) 
2025-04-24 | PXD050979 | Pride
Mass spectrometry Cell culture Immune response Ferroptosis Secretome 
ProteomicsTRAIL-induced cancer secretome
To comprehensively determine which factors are secreted by cancer cells upon TRAIL stimulation, we conducted an unbiased mass spectrometric analysis of TRAIL’s secretome in resistant A549 cells.
ORGANISM(S): Homo sapiens (Human) 
2017-12-19 | PXD005664 | Pride
A549 cells Lable-free quantification 
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