Browse
Submit Data
Databases
API
Help

Dataset Information

8 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

E-GEOD-16879

ABSTRACT: Mucosal expression profiling in patients with inflammatory bowel disease before and after first infliximab treatment

OTHER RELATED OMICS DATASETS IN: PRJNA117589

PROVIDER: E-GEOD-16879 | ExpressionAtlas | 2015-07-28

REPOSITORIES: ExpressionAtlas

ACCESS DATA

Json Xml

Similar Datasets

Homo sapiens

Project description:Mucosal expression profiling in patients with inflammatory bowel disease before and after first infliximab treatment

| PRJNA117589 | ENA

Mucosal expression profiling in patients with inflammatory bowel disease before and after first infliximab treatment

Project description:We used microarrays to identify mucosal gene signatures predictive of response to infliximab (IFX) in patients with inflammatory bowel disease (IBD) and to gain more insight into the pathogenesis of IBD. Keywords: drug response and treatment effect Mucosal biopsies were obtained at endoscopy in actively inflamed mucosa from 61 IBD patients (24 ulcerative colitis (UC), 19 Crohnâs colitis (CDc) and 18 Crohnâs ileitis (CDi)), refractory to corticosteroids and/or immunosuppression, before and 4-6 weeks after (except for 1 CDc patient) their first infliximab infusion and in normal mucosa from 12 control patients (6 colon and 6 ileum). The patients were classified for response to infliximab based on endoscopic and histologic findings at 4-6 weeks after first infliximab treatment. Total RNA was isolated from intestinal mucosal biopsies, labelled and hybridized to Affymetrix Human Genome U133 Plus 2.0 Arrays.

2009-11-02 | E-GEOD-16879 | biostudies-arrayexpress

Homo sapiens

Project description:Mucosal gene expression profiling in patients with inflammatory bowel disease

| PRJNA254329 | ENA

Homo sapiens

Project description:Mucosal gene expression profiling in patients with inflammatory bowel disease study

| PRJNA302811 | ENA

Associations between cellular energy and pediatric inflammatory bowel disease patient response to treatment

Project description:Crohn’s disease (CD) and ulcerative colitis are chronic inflammatory bowel diseases (IBD) of which the etiology and pathogenesis are not completely understood. In paediatric patients, the disease tends to be more severe and aggressive then in adults. Here, we perform a proteomic approach on ascending colon biopsies from 119 pediatric patients to characterize disease pathogenesis and the impacts of treatment. Consistent with previous findings, we report an altered proteome in IBD patients that indicates impaired mitochondrial function. Gene ontology revealed that proteins downregulated in inflammation are associated with metabolism, whereas upregulated proteins contribute to protein processing. A comparison of proteomes from CD patients before and after therapeutic intervention identified over 100 proteins that are significantly different between patients that responded and those that did not respond to therapy; creatine kinase B was elevated before treatment in patients with mucosal healing after treatment, whereas basigin increased after treatment in responsive patients.

2021-08-26 | PXD024229 | Pride

Human colon aspirate proteins analyzed by LC-MSMS

Project description:Colonic aspirates were collected at diagnostic colonoscopy from inflammatory bowel disease (IBD) and control, treatment-naive children. The colonic mucosal-luminal interface (MLI) proteomes were analyzed for 18 control and 42 IBD patients by liquid-chromatography mass spectrometry.

2018-03-19 | PXD006383 | Pride

Mucosal gene expression profiling in patients with inflammatory bowel disease

Project description:Microarrays were used to analyze the gene expression in endoscopic-derived intestinal mucosal biopsies from patients with inflammatory bowel disease (IBD) and controls

2015-05-27 | GSE59071 | GEO

Mucosal expression profiling in patients with inflammatory bowel disease before and after first infliximab treatment

2009-11-03 | GSE16879 | GEO

Microarray analysis of colonic mucosa biopsies in patients with inflammatory bowel disease

Project description:Microarrays were used to analyze the gene expression in endoscopic-derived intestinal mucosal biopsies from patients with inflammatory bowel disease (IBD) and controls Mucosal biopsies were obtained at endoscopy from the colon of 97 ulcerative colitis (UC), 8 Crohn's disease (CD) patients and 11 controls. The biopsies were taken at the most affected sites but at a distance of ulcerations. Disease activity was endoscopically assessed. Total RNA extracted from mucosal biopsies was used to analyze mRNA expression via Affymetrix Human Gene 1.0 ST arrays

2015-05-27 | E-GEOD-59071 | biostudies-arrayexpress

Altered mucosal expression of microRNAs in pediatric patients with inflammatory bowel disease

Project description:Altered mucosal expression of microRNAs in pediatric patients with inflammatory bowel disease

| PRJEB15041 | ENA