Dataset Information


Associations between cellular energy and pediatric inflammatory bowel disease patient response to treatment

ABSTRACT: Crohn’s disease (CD) and ulcerative colitis are chronic inflammatory bowel diseases (IBD) of which the etiology and pathogenesis are not completely understood. In paediatric patients, the disease tends to be more severe and aggressive then in adults. Here, we perform a proteomic approach on ascending colon biopsies from 119 pediatric patients to characterize disease pathogenesis and the impacts of treatment. Consistent with previous findings, we report an altered proteome in IBD patients that indicates impaired mitochondrial function. Gene ontology revealed that proteins downregulated in inflammation are associated with metabolism, whereas upregulated proteins contribute to protein processing. A comparison of proteomes from CD patients before and after therapeutic intervention identified over 100 proteins that are significantly different between patients that responded and those that did not respond to therapy; creatine kinase B was elevated before treatment in patients with mucosal healing after treatment, whereas basigin increased after treatment in responsive patients.

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Colon

DISEASE(S): Inflammatory Bowel Disease 1

SUBMITTER: Zhibin Ning  

LAB HEAD: Daniel Figeys

PROVIDER: PXD024229 | Pride | 2021-08-26


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Associations between Cellular Energy and Pediatric Inflammatory Bowel Disease Patient Response to Treatment.

Starr Amanda E AE   Deeke Shelley A SA   Ning Zhibin Z   de Nanassy Joseph J   Singleton Ruth R   Benchimol Eric I EI   Mack David R DR   Stintzi Alain A   Figeys Daniel D  

Journal of proteome research 20210823 9

Inflammatory bowel diseases (IBDs), including Crohn's disease (CD) and ulcerative colitis, are chronic diseases of the gastrointestinal tract, with an unknown etiology, that affect over 6.8 million people worldwide. To characterize disease pathogenesis, proteomic and bioinformatic analyses were performed on colon biopsies collected during diagnostic endoscopy from 119 treatment-naïve pediatric patients, including from 78 IBD patients and 41 non-IBD patients who served as controls. Due to the pre  ...[more]

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