Project description:To investigate the impact of TGFb on CD8 T cell activation and gene expression, we activated TCR transgenic OT-I T cells in the presence or absence of recombinant TGFb in vitro

2022-06-10 | GSE205654 | GEO

T cells activated in the presence or absence of TLR agonists

Project description:We report the gene expression differences between OT-1 T cells activated alone or in the presence of TLR1/2 (Pam3CSK4) or TLR7 (Gardiquimod). By activating OT-1 splenocytes in the presence or absence of the TLR agonists, isolating RNA from purified CD8+ T cells we show that cells activated in the presence of either TLR1/2 or TLR7 agonists had similar transcriptional profiles demonstrating an increase in Th1 cytokine expression over cells that were activated alone. This study provides a key piece of information for those designing T cell mediated therapies.

2018-12-26 | GSE110144 | GEO

Global gene expression changes during immune complex-induced neutrophil activation (wild type and Card9â??/â?? cells)

Project description:--- Raw data of the Supplementary Table 1 of the Nature Communications article 'Neutrophil-specific deletion of the CARD9 gene expression regulator suppresses autoantibody-induced inflammation in vivo' We used microarray to obtain global gene expression data of immobilised immune complex-activated mouse neutrophils in the presence and absence of the gene expression regulator molecule CARD9. Mouse neutrophils were isolated from the bone marrow and were plated on human serum albumin & anti-human serum albumin antibody-coated surfaces at a 4 x 106 cell concentration. Human serum albumin-coated surfaces served as controls. The cells were stimulated for 4 hours before RNA preparation. The experiments were done at 3 independent timepoints.

2016-02-29 | E-GEOD-78066 | biostudies-arrayexpress

RNAseq data for ex vivo Naïve CD8+ T cells and TCR activated 24hr in the presence or absence of PI3Kp110δ inhibitor

Project description:RNAseq data for ex vivo Naïve CD8+ T cells and TCR activated 24hr in the presence or absence of PI3Kp110δ inhibitor

| PRJNA716601 | ENA

Mus musculus

Project description:Expression data from naive and memory CD8 T cells cultured in presence or absence of IL-4

| PRJNA147911 | ENA

T cells activated in the presence or absence of TLR agonists

Project description:T cells activated in the presence or absence of TLR agonists

| PRJNA432950 | ENA

Mus musculus

Project description:Expression data from Klf4 KD cells in the presence and absence of TGFβ in NMuMG cells

| PRJNA213150 | ENA

Mus musculus

Project description:Expression data from Sox4 knockdown cells in the presence and absence of TGFβ in NMuMG cells

| PRJNA188448 | ENA

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